Mathews Journal of Case Reports Hydranencephaly Mohammad Nawaz Nasery1, Farhad Farzam1, Hidayatullah Hamidi2, Jamshid Sadiqi2, Ahmad Reshad Faizi2, Fazel Rahman Faizi2, Marzia Mohammadi2 1Radiology department, Ali Abad Teaching Hospital, Kabul, Afghanistan. 2Radiology department, French Medical Institute for Children (FMIC), Kabul, Afghanistan. Corresponding Author: Mohammad Nawaz Nasery, Ali A...

Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of AD patients and transgenic mice. The crystal structure of Abeta-bound ABAD shows substantial de...

Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to construct a fusion gene that can express the TRX1-A...

Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, and cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting mitochondrial ABAD may represent a novel therapeutic strategy against AD. Here, we report the biological activity of small molecule ABAD inhibitors. Using in vitro su...

due to successes of fingerprinting method in producing rapid and low-cost information of sediment sources, in this research this method was used in three sub-cathments of chasht-khoran basin in semnan province: amrovan, atari and ali-abad. samples below 63 μm were separated and 15 fingerprinting propertis was measured. in the first stage comparison of means and differentiation analysis were use...

genetic structure and pathogenic diversity of sclerotinia sclerotiorum, the causal agent of canola white stem rot, were assessed through mycalial compatibility groupings (mcgs), a comparison and comparing of isolate virulence. fifty-seven isolates from three different regions in golestan province were selected for mycelial compatibility and as well for virulence tests. within the 57 tested isol...

Patients with acute type B aortic dissection (ABAD) are often treated medically. However, ABAD is a potentially serious emergency if complicated by acute organ ischemia. The therapeutic strategy for ABAD with visceral malperfusion remains controversial. Because emergent surgery has a high mortality rate, emergent endovascular treatment can be performed instead. We report a case of endovascular ...

the study area is a part of cenozoic magmatic belt of central iran, which is located in the west of yazd porovince. contact metamorphism and skarn occurred in conglomerate part of sngestan formation. the oligocene intrusion bodies of ali-abad-darreh zereshk are leucocerate and have the chemical composition of granite to granodiorite with calc-alkaline affinity from volcanic arc geological setti...