wiskott-aldrich syndrome (was) is a life-threatening x-linked recessive immunodeficiency disease described as a clinical triad of thrombocytopenia,  eczema, and recurrent infections, caused by mutations of the was protein (wasp) gene. the milder form of this disease is x-linked thrombocytopenia  (xlt) that  presents only as platelet abnormalities. mutation analysis for 15 boys with wiskott-aldr...

wiskott-aldrich is an x-lined recessive disorder typically characterized by thrombocytopenia, eczema and recurrent infections. we report the four year treatment progress of a six year old boy who initially presented with vesicular lesions over the trunk, upper and lower extremities and face and blood tinged stools at the age of 2 weeks. from the family pedigree, there were two suspected cases t...

Wiskott-Aldrich is an X-lined recessive disorder typically characterized by thrombocytopenia, eczema and recurrent infections. We report the four year treatment progress of a six year old boy who initially presented with vesicular lesions over the trunk, upper and lower extremities and face and blood tinged stools at the age of 2 weeks. From the family pedigree, there were two suspected cases t...

All the experiments in the paper were conducted using these materials : CdO (99.999%, Strem Chemicals, MA, USA), Se (99.999%, Alfa-Aesar, MA, USA), trioctylphosphine (TOP; 97%, SigmaAldrich, Israel), trioctylphosphine oxide (TOPO; 99%, Sigma-Aldrich, Israel), octadecylphosphonic acid (ODPA; 99%, Polycarbon Industries, MA, USA), S (99.98%, Sigma-Aldrich, Israel), oleic acid (90%, Alfa-Aesar, MA,...

Podosomes are actin-based adhesions involved in migration of cells that have to cross tissue boundaries such as myeloid cells. The Wiskott Aldrich Syndrome Protein regulates de novo actin polymerization during podosome formation and it is cleaved by the protease calpain during podosome disassembly. The mechanisms that may induce the Wiskott Aldrich Syndrome Protein cleavage by calpain remain un...