The distribution of phenylacetaldoxime-degrading and pyridine-3-aldoxime-degrading ability was examined with intact cells of 975 microorganisms, including 45 genera of bacteria, 11 genera of actinomyces, 22 genera of yeasts, and 37 genera of fungi, by monitoring the decrease of the aldoximes by high-pressure liquid chromatography. The abilities were found to be widely distributed in bacteria, a...

A rapid and accurate method for analyzing pyridinium oximes-N-methylpyridinium2-aldoxime chloride, N,N’-trimethylene-(pyridinium-4-aldoxime) dihalide, and N,N’oxydimethyl(pyridinium-4-aldoxime) dich bride-in plasma, urine, and whole blood is described.The method is completely automated and requires small sample volumes. Concentrations ranging from 3 to 120 Eq./L. in biologic fluids can be deter...

A BODIPY-based fluorescent probe integrated with an aldoxime unit shows a remarkable fluorescence ''turn-on'' response to hypochlorous acid (HOCl). The oxidative dehydrogenation of BODIPY aldoxime by HOCl results in a distinct fluorescence enhancement as well as a change in color from red to orange.

Aldoxime dehydratase (OxdA), which is a novel heme protein, catalyzes the dehydration of an aldoxime to a nitrile even in the presence of water in the reaction mixture. The combination of site-directed mutagenesis of OxdA (mutation of all conserved histidines in the aldoxime dehydratase superfamily), estimation of the heme contents and specific activities of the mutants, and CD and resonance Ra...

This paper describes an in vitro study of three potential acetylcholinesterase (AChE; EC 3.1.1.7) reactivators derived from a monoquaternary reactivator pralidoxime. Compounds used were pyridinium-2-aldoxime-4-carbamoyl-N-methyl iodide (TO231), pyridinium-2-aldoxime-4-ethoxycarbonyl-N-methyl iodide (TO237), and pyridinium-2-aldoxime-5-ethoxycarbonyl-N-methyl iodide (TO238). Pralidoxime and obid...

In the title complex, [Ir(C11H8N)2(C6H5N2O)], the octa-hedrally coordinated Ir(III) atom is bonded to two 2-(pyridin-2-yl)phenyl ligands, through two phenyl C and two pydidine N atoms, and to one pyridine-2-aldoxime ligand through a pyridine N and an oxime N atom. The oxime O atom of the aldoxime unit forms inter-molecular C-H⋯O hydrogen bonds, which result in a two-dimensional hydrogen-bonded ...

Bacillus sp. OxB-1 has been characterized as a strain that produces a new enzyme, aldoxime dehydratase, which catalyzes the dehydration of aldoxime to form nitrile. Here, its complete genome sequence (3,594,618 bp, with a GC content of 47.85%), comprising a circular chromosome, is announced.

In the title mol-ecule, [Cd(CH(3)COO)(2)(C(6)H(6)N(2)O)(2)], the Cd(II) cation is N,N'-chelated by two 2-pyridine-aldoxime ligands and coordinated by two acetate anions in a distorted octa-hedral geometry. The hy-droxy groups of the 2-pyridine-aldoxime ligands link to the acetate anions via intra-molecular O-H⋯O hydrogen bonds. Weak inter-molecular C-H⋯O hydrogen bonds occur in the crystal.

During studies directed towards the discovery of nitrile hydrolysing enzymes from thermophiles, vanillin aldoxime was incubated with the thermophilic organism, Geobacillus sp. DDS012 isolated from Italian rye grass (Lolium multiflorum) silage. The predominant product was a dihydro-dimer, which could only be characterised by LC-MS. This was initially imagined to be the product of cycloaddition o...

We investigated interactions of bispyridinium para-aldoximes N,N'-(propano)bis(4-hydroxyiminomethyl) pyridinium bromide (TMB-4), N,N'-(ethano)bis(4-hydroxyiminomethyl)pyridinium methanosulphonate (DMB-4), and N,N'-(methano)bis(4-hydroxyiminomethyl)pyridinium chloride (MMB-4) with human erythrocyte acetylcholinesterase phosphorylated by tabun. We analysed aldoxime conformations to determine the ...