Gene duplication is one of the major evolutionary mechanisms providing raw material for the generation of genes with new or modified functions. The yeast Saccharomyces cerevisiae originated after an allopolyploidization event, which involved mating between two different ancestral yeast species. ScALT1 and ScALT2 codify proteins with 65% identity, which were proposed to be paralogous alanine tra...

conclusions based on our results, the administration of fe3o4-nps causes dose dependent adverse effects on liver. background because of their unique magnetic properties, fe3o4 nanoparticles (fe3o4-nps) have extensive applications in various biomedical aspects. investigation of the possible adverse aspects of these particles has lagged far behind their fast growing application. objectives the cu...

Abbreviations: VGKC: Voltage-gated Potassium Channel; NMDAR: N-methyl, D-aspartate Receptor; LGI 1: Leucin-Rich Glioma-Inactivated-1; CASPR 2: Contact in-Associated Protein-2; SE: Status Epilepticus; WBC: White Blood Count; ALT: Alanine Transaminases; AST: Aspartate Transaminases; HSV-1: Herpes Simplex Virus; PCR : Polymerase Chain Reaction; EEG: Electro Encephalogram; CT: Computed Tomography; ...

BACKGROUND Persistently raised transaminase levels often prompt the clinician to investigate for liver pathology. Previously, some of our patients with Duchenne's muscular dystrophy have had investigations to look for liver disorders when the alanine transaminases (ALTs) were found incidentally to be high. AIM The objective of the study was to ascertain the levels of the transaminases in pati...

1. Alanine Aminotransferase (ALT) Alanine aminotransferase measurements are used in the diagnosis and treatment of certain liver diseases (e.g., viral hepatitis and cirrhosis) and heart diseases. Elevated levels of the transaminases can indicate myocardial infarction, hepatic disease, muscular dystrophy, or organ damage. Serum elevations of ALT activity are rarely observed except in parenchymal...

Clindamycin is a bacteriostatic lincosamide antibiotic with a broad spectrum. Side effects include nausea, vomiting, diarrhea, and metallic taste; however, hepatotoxicity is rare. The incidence is unknown. It is characterized by increases in aspartate and alanine transaminases. There may be no symptoms and the treatment is to stop the administration of clindamycin. We have described a 62-year-o...

OBJECTIVES To evaluate gamma-glutamyltransferase (GGT), alanine transaminases (ALT) and aspartate transaminases (AST) levels and prevalent gestational diabetes mellitus (GDM). DESIGN AND METHODS Random plasma glucose, GGT, ALT and AST and the 50-g glucose challenge test were done on antenatal women followed by diagnostic 3-point 75-g oral glucose tolerance test within two weeks. GDM was diagn...

Transaminases have arisen as one of the main biocatalysts for amine production but despite their many advantages, stability is still a concern widespread application. One reasons instability need to use an excess amino donor when trying synthesise amines with unfavourable equilibria. To circumvent this, recycling systems donor, such acid dehydrogenases or aldolases, proved useful push equilibri...