et al. Improved sexual function during recombinant human erythropoietin therapy. The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin [see comments]. Valderrabano F. Increasing the hematocrit has a beneficial effect on quality of life and is safe in selected hemodialysis patients. Spanish Cooperative Renal Patie...

Left atrial masses, namely thrombi or myxomas, are confidently diagnosed by means of two-dimensional echo-cardiography' 11. By transthoracic echocardiography, diagnostic specifi-city is reported to be high, while sensitivity is relatively low* \ Trans-oesophageal echocardiography is the technique of choice with which to detect left atrial masses' 3-41. We report a case of left atrial thrombus p...

objective(s):  the role of the apoptosis repressor with caspase recruitment domain (arc) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of endothelin-1 induced cardiac hypertrophy remains unknown. the present study discusses the inhibitory role of arc against endothelin–induced hypertrophy. results:in present study endothelin treated card...

PuRPOSe To create a simple algorithm of choice for bilateral mastectomy in female-to-male transsexuals. MethOdS On the basis of our clinical experience of more than 400 bilateral mastectomies performed since 1993, we distinguish 3 different approaches: Type 1, bilateral subcutaneous mastectomy performed through semicircular incision at the border nipple-areola complex; Type 2, bilateral subcuta...

Background—Secretoneurin is a neuropeptide located in nerve fibers along blood vessels, is upregulated by hypoxia, and induces angiogenesis. We tested the hypothesis that secretoneurin gene therapy exerts beneficial effects in a rat model of myocardial infarction and evaluated the mechanism of action on coronary endothelial cells. Methods and Results—In vivo secretoneurin improved left ventricu...

Bronchopulmonary dysplasia (BPD) is a chronic lung disease associated with under development of lung tissue, mainly occurring in premature and extremely low birth weight infants. BPD has a poor prognosis in morbidity and mortality but BPD with pulmonary hypertension and right ventricular (RV) dys-function has worse prognosis. 1) Early detection for pulmonary hypertension and RV dysfunction is i...

Right ventricular (RV) structure and function serve as important indicators of a wide spectrum of heart diseases such as congenital heart disease, pulmonary hypertension, hypertro-phic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy/disease (ARVC/D) [1–3]. Over the past years cardiac magnetic resonance imaging (CMR) has proven itself as the preferred imaging modality of choic...

2ϩ-calmodulin, participates in signaling pathways valvular dysfunction, from ischemic injury following cor-important for gene regulation and biological responses onary artery occlusion, or from mutations in genes en-to external stimuli in many organisms and in many types coding proteins of the sarcomere. Initially, this remodel-of cells (Crabtree, 1999). Calcineurin-dependent signal-ing respons...

Background—Pharmacological interventions for prevention of sudden arrhythmic death in patients with chronic heart failure remain limited. Accumulating evidence suggests increased ventricular expression of T-type Ca 2ϩ channels contributes to the progression of heart failure. The ability of T-type Ca 2ϩ channel blockade to prevent lethal arrhythmias associated with heart failure has never been t...

It was suggested that the enhanced incorporation of choline into phospholipids in the very first stages of renal compensatory hypertrophy might result in a change of membrane fatty acid composition and of membrane fluidity (S. Solomon). L. M. Lowenstein stated that no data on fatty acid composition of kidneys undergoing compensatory hypertrophy were available. Since ligation of the ureter of th...