نتایج جستجو برای: ag85 complex

تعداد نتایج: 783874  

2011
Pascal Launois Annie Drowart Eliane Bourreau Pierre Couppie Claire-Michèle Farber Jean-Paul Van Vooren Kris Huygen

The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infecte...

Journal: :Infection and immunity 1999
S I Bentley-Hibbert X Quan T Newman K Huygen H P Godfrey

Antigen 85 (Ag85) complex proteins are major secretory products of Mycobacterium tuberculosis and induce strong cellular and humoral immune responses in infected experimental animals and human beings. We have previously shown that nanogram doses of these 30- to 32-kDa fibronectin-binding proteins inhibit local expression of delayed hypersensitivity by a T-cell fibronectin-dependent mechanism. C...

Journal: :modares journal of medical sciences: pathobiology 2012
haniyeh aghababa ashraf mohabbati mobarez mehrdad behmanesh nima khoramabadi mehdi nejati

objective: antigen 85 complex of mycobacterium tuberculosis includes three immunogenic proteins which are important tb vaccine candidates. the use of these protein as a component of subunit vaccines, as a part of dna vaccines or recombinant bcg boosters, enhances their recombinant production. recombinant production of these mycobacterial proteins located in the cell wall somehow differs from th...

Journal: :The Journal of biological chemistry 2014
Lorenza Favrot Daniel H Lajiness Donald R Ronning

The rise of multidrug-resistant and totally drug-resistant tuberculosis and the association with an increasing number of HIV-positive patients developing tuberculosis emphasize the necessity to find new antitubercular targets and drugs. The antigen 85 (Ag85) complex from Mycobacterium tuberculosis plays important roles in the biosynthesis of major components of the mycobacterial cell envelope. ...

2013
Lorenza Favrot Anna E. Grzegorzewicz Daniel H. Lajiness Rachel K. Marvin Julie Boucau Dragan Isailovic Mary Jackson Donald R. Ronning

The increasing prevalence of drug-resistant tuberculosis highlights the need for identifying new antitubercular drugs that can treat these infections. The antigen 85 (Ag85) complex has emerged as an intriguing mycobacterial drug target due to its central role in synthesizing major components of the inner and outer leaflets of the mycobacterial outer membrane. Here we identify ebselen (EBS) as a...

Journal: :Journal of bacteriology 2007
Tomoya Katsube Sohkichi Matsumoto Masaki Takatsuka Megumi Okuyama Yuriko Ozeki Mariko Naito Yukiko Nishiuchi Nagatoshi Fujiwara Mamiko Yoshimura Takafumi Tsuboi Motomi Torii Nobuhide Oshitani Tetsuo Arakawa Kazuo Kobayashi

Bacteria coordinate assembly of the cell wall as well as synthesis of cellular components depending on the growth state. The mycobacterial cell wall is dominated by mycolic acids covalently linked to sugars, such as trehalose and arabinose, and is critical for pathogenesis of mycobacteria. Transfer of mycolic acids to sugars is necessary for cell wall biogenesis and is mediated by mycolyltransf...

Journal: :The Journal of biological chemistry 2012
Chih-Jung Kuo Hannah Bell Ching-Lin Hsieh Christopher P Ptak Yung-Fu Chang

The members of the antigen 85 protein family (Ag85), consisting of members Ag85A, Ag85B, and Ag85C, are the predominantly secreted proteins of mycobacteria and possess the ability to specifically interact with fibronectin (Fn). Because Fn-binding proteins are likely to be important virulence factors of Mycobacterium spp., Ag85 may contribute to the adherence, invasion, and dissemination of orga...

2014
Kris Huygen

The Ag85 complex is a 30-32 kDa family of three proteins (Ag85A, Ag85B, and Ag85C), which all three possess enzymatic mycolyl-transferase activity involved in the coupling of mycolic acids to the arabinogalactan of the cell wall and in the biogenesis of cord factor. By virtue of their strong potential to induce Th1-type immune responses, important for the control of intracellular infections, me...

2018
Bruno Cerqueira-Rodrigues Ana Mendes Margarida Correia-Neves Claudia Nobrega

CD4+ T cells are essential players for the control of mycobacterial infections. Several mycobacterial antigens have been identified for eliciting a relevant CD4+ T cell mediated-immune response, and numerous studies explored this issue in the context of Mycobacterium tuberculosis infection. Antigen 85 (Ag85), a highly conserved protein across Mycobacterium species, is secreted at the early phas...

Journal: :Journal of immunology 2000
A Geluk K E van Meijgaarden K L Franken J W Drijfhout S D'Souza A Necker K Huygen T H Ottenhoff

CD8(+) T cells are thought to play an important role in protective immunity to tuberculosis. Although several nonprotein ligands have been identified for CD1-restricted CD8(+) CTLs, epitopes for classical MHC class I-restricted CD8(+) T cells, which most likely represent a majority among CD8(+) T cells, have remained ill defined. HLA-A*0201 is one of the most prevalent class I alleles, with a f...

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