BACKGROUND To evaluate the age-adjusted Framingham risk score (AFRS), flow-mediated dilation (FMD) and brachial-ankle pulse wave velocity (baPWV) for the prediction of the coronary heart disease (CHD) in patients with stable angina. METHODS AND RESULTS In 138 consecutive patients with stable angina, the interrelationship and predictive power of CHD were compared between the study parameters. ...

Objective: We investigated hepatoprotective and antioxidant activity of extracted anthocyanins fraction of red radish for the first time. Methods: Anthocyanins fraction of red radish (Raphanus sativus; AFRS) was selectively extracted by employment of polymeric ion-exchange resin. AFRS was evaluated for antioxidant and hepatoprotective activity against carbon tetrachloride (CCl4)-induced hepatot...

BACKGROUND Allergic fungal rhinosinusitis (AFRS) is a subset of polypoid chronic rhinosinusitis that is characterized by the presence of eosinophilic mucin with fungal hyphae within the sinuses and a Type I hypersensitivity to fungi. The treatment of AFRS usually involves surgery in combination with medical therapies to keep the disease in a dormant state. However, what constitutes an optimal m...

OBJECTIVES Chronic rhinosinusitis (CRS) with eosinophilic mucin is relatively rare in Korea. We categorized CRS patients with characteristic eosinophilic mucin into several groups and compared the groups based on their clinicopathological features. METHODS In total, 52 CRS patients with eosinophilic mucin were enrolled. Based on the presence or absence of an allergy (A) to a fungus or fungal ...

BACKGROUND Local tissue production of antigen-specific immunoglobulin E (IgE) has been shown in patients with allergic rhinitis and in patients with chronic rhinosinusitis (CRS) with nasal polyps. In allergic fungal rhinosinusitis (AFRS), specific IgE has been established in nasal lavage fluid and eosinophilic mucin. In this study, local production of antigen-specific IgE within sinus mucosa of...

OBJECTIVES To compare the effect of preoperative high-dose systemic corticosteroids on the radiographic and endoscopic appearance of allergic fungal rhinosinusitis (AFRS) and chronic rhinosinusitis with nasal polyposis (CRSwNP). STUDY DESIGN AND SETTING Eight AFRS and 10 CRSwNP patients underwent computed tomographic (CT) scans and then received preoperative 1 mg/kg prednisone for 10 days. CT...

OBJECTIVE To resolve the diagnostic dilemma of allergic fungal rhinosinusitis (AFRS), an increasingly recognized type of chronic rhinosinusitis (CRS). In spite of extensive studies, controversy exists regarding the etiologic characteristics, pathogenesis, and diagnosis of this entity. DESIGN Prospective, comparative study. SETTING Department of Otolaryngology-Head and Neck Surgery, Postgrad...

Allergic fungal rhinosinusitis (AFRS) is a unique variety of chronic polypoid rhinosinusitis usually in atopic individuals, characterized by presence of eosinophilic mucin and fungal hyphae in paranasal sinuses without invasion into surrounding mucosa. It has emerged as an important disease involving a large population across the world with geographic variation in incidence and epidemiology. Th...

OBJECTIVE To correlate patient reports of olfactory dysfunction after surgical intervention for allergic fungal rhinosinusitis (AFRS) with endoscopic findings, psychophysical testing, and quality-of-life scores. DESIGN A prospective cohort study. SETTING A tertiary care rhinology clinic at St Paul's Hospital, Vancouver, British Columbia, Canada. PATIENTS Eighty-one patients with AFRS seen...

Fungi in paranasal sinuses are characteristic and considered a major pathogenic factor in a subset of chronic rhinosinusitis (CRS) patients, known as allergic fungal rhinosinusitis (AFRS). CD8(+) T cells are enriched in AFRS sinuses but their role in fungal-specific responses is unknown. Alternaria alternata- and Aspergillus fumigatus-specific T lymphocyte responses were investigated in 6 AFRS ...