Whilst nebulisers are commonly used in the treatment of cystic fibrosis (CF), nebulised aerosol lung deposition in individual patients is not routinely assessed in clinical practice. The present study was designed to evaluate whether a comparative measurement of aerosol lung deposition from nebulisers using a widely available scintigraphic method could be employed to assist the selection of the...

BACKGROUND A previous PET-CT imaging study of 14 bronchoconstricted asthmatic subjects showed that peripheral aerosol deposition was highly variable among subjects and lobes. The aim of this work was to identify and quantify factors responsible for this variability. METHODS A theoretical framework was formulated to integrate four factors affecting aerosol deposition: differences in ventilatio...

This paper is concerned with asphaltene deposition in fluid flowing through pipelines. Brownian diffusion and drag, gravitational, thermophoresis, buoyancy, and shear removal are considered as possible mechanisms in the asphaltene deposition process. The thermo-physical properties of the fluid were obtained from Iranian oil fields. A model was used in the pipeline deposition modeling to predict...

AIMS To investigate (1) aerosol lung deposition obtained from two small volume conventional spacers (Babyhaler and Aerochamber) and a home made spacer (modified 500 ml plastic cold drink bottle); (2) the effect of using a face mask or mouthpiece; and (3) the relation between age and pulmonary deposition. METHODS Lung deposition of aerosolised technetium-99m DTPA inhaled via spacer was measure...

PURPOSE Aerosol inhalation therapy is one of the methods to treat rhinosinusitis. However the topical drug delivery to the posterior nose and paranasal sinuses shows only limited efficiency. A precise sinusal targeting remains a main challenge for aerosol treatment of sinus disorders. This paper proposes a comparative study of the nasal deposition patterns of micron and submicron particles usin...

BACKGROUND While it is generally accepted that inertial impaction will lead to particle loss as aerosol is being carried into the pulmonary airways, most predictive aerosol deposition models adopt the hypothesis that the inhaled particles that remain airborne will distribute according to the gas flow distribution between airways downstream. METHODS Using a 3D printed cast of human airways, we...

To relate exposure to adverse health effects, it is necessary to know where particles in the submicron range deposit in the respiratory tract. The possibly higher vulnerability of children requires specific inhalation studies. However, radio-aerosol deposition experiments involving children are rare because of ethical restrictions related to radiation exposure. Thus, an in vivo study was conduc...

An analytical model is used .to describe the behavior of inhaled particulate matter in the human respiratory tract. Three different geometries, symmetric and asymmetric, are utilized to simulate the tracheobronchial (TB) tree. The suitability of each geometry for representing the human is evaluated by comparing calculated aerosol deposition probabilities with experimental data from inhalation e...

Several factors interact in influencing aerosol deposition during mechanical ventilation. Among these factors, the artificial airway is a significant barrier for aerosol deposition. Earlier studies overemphasized the impediments created by the artificial airway to aerosol delivery, because the aerosol generator was placed adjacent to the endotracheal tube or was connected to it. When the aeroso...

Fluxes of aerosol polychlorinated biphenyl (PCB, 54% chlorine mixture) ranging from 2 X lov9 to 9 X (average: 3 X g m-2 day-l were measured a t La Jolla, Calif., during February and October 1972. A model for mesoscale aerosol transport which treats the plume as a superposition of Gaussian-shaped puffs diffusing isotropically in the plane of the horizon was used with the assumption that depositi...