in this study we investigated the effects of endothelium removal and l-name on responses to α-adrenoceptor agonists. male wistar rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. rings of arteries 3-4 mm in length were cut from each vessel and then mounted in 10 ml isolated organ bath, bathed in krebs maintained at 37°c...

Administration of apomorphine and amphetamine induces climbing behavior in mice due to stimulation of brain dopamine receptors. In the present study, the effects of adrenoceptor agonists and antagonists on amphetamine-induced climbing have been investigated. Intraperitoneal (i.p.) injection of different doses of amphetamine (2,4 and 8 mglkg) induced climbing in mice (p<O.OOO 1). The u2- ad...

The actions of orand /8-adrenoceptor agonists, antagonists and ATP were investigated on the smooth muscle of the guinea-pig taenia coli. Electrical and mechanical activities were recorded by means of the sucrose gap method. Noradrenaline, phenylephrine and methoxamine hyperpolarized the smooth muscle membrane, decreased the membrane resistance, reduced the size of phasic contractions, decreased...

Previous in vitro work on rabbit knee joint vessels showed that vasoconstrictor effects of nerve stimulation and administration of α-adrenoceptor agonists were mediated predominantly by α1-adrenoceptors5,9 The present experiments were performed to assess the nature of α-adrenoceptor subtypes within these blood vessels in vivo. Dose/response relationships for adrenaline and noradrenaline pr...

Agonists of ?2-adrenoceptors are increasingly being used for the provision comfort, sedation and management delirium in critically ill patients, with without sepsis. In this context, increased sympathetic inflammatory activity common pathophysiological features linked to multi-organ dysfunction, particularly patients sepsis or those undergoing cardiac surgery requiring cardiopulmonary bypass. E...

In the present study, we examined the inhibitory effects of the beta2-adrenoceptor agonists isoproterenol, salbutamol, fenoterol, and clenbuterol, on the release of chemical mediators from cultured human mast cells after prolonged treatment with the agonists. Although preincubation of sensitized mast cells for 10 min with beta2-adrenoceptor agonists potently inhibited mediator release, prolonga...

It has been shown that inflammation reduces the effectiveness of sympathetic nerves in the regulation of knee joint blood flow, and the joint vascular- ß adrenoceptors are changed due to acute inflammation from a majority of ß-1 to an equality of ß-1 and ß-2 receptors.. To investigate the role of sympathetic nerves in nerve induced vasoconstriction and changes in joint vascular ß-adrenoceptors ...

administration of apomorphine and amphetamine induces climbing behavior in mice due to stimulation of brain dopamine receptors. in the present study, the effects of adrenoceptor agonists and antagonists on amphetamine-induced climbing have been investigated. intraperitoneal (i.p.) injection of different doses of amphetamine (2,4 and 8 mglkg) induced climbing in mice (p

previous in vitro work on rabbit knee joint vessels showed that vasoconstrictor effects of nerve stimulation and administration of α-adrenoceptor agonists were mediated predominantly by α1-adrenoceptors5,9 the present experiments were performed to assess the nature of α-adrenoceptor subtypes within these blood vessels in vivo. dose/response relationships for adrenaline and noradrenaline produce...

BACKGROUND Long-acting β2-adrenoceptor agonists have been shown to increase the risk of atrial arrhythmias in patients with stable chronic obstructive pulmonary disease. The aim of this study was to investigate whether perioperative long-acting β2-adrenoceptor agonists treatment would increase the risk of postoperative atrial arrhythmias after lung cancer surgery in chronic obstructive pulmonar...