the prevalence of mental health disorders continues to rise worldwide, such that it is estimated that 1in 4 individuals will be affected by a mental health disorder at some point in their lifetime. research has found that the most prevalent mental health disorders are depressive disorder. depression is a common condition, particularly within the aging population. the development of depression, ...

conclusions whenever a cushingoid appearance is accompanied by adrenal insufficiency, the exogenous use of steroids, especially topical creams, should be explored. hypertension may persist even after cessation of use and may result in life threatening complications. case presentation the present report describes the cases of three children and a 25-year-old man who presented with clinical featu...

the hypothalamo-pituitary-adrenocortical (hpa) axis is a critical adaptive system that maximizes survival potential in the face of physical or psychological challenge. the principal end products of the hpa axis, glucocorticoid hormones, act on multiple organ systems, including the brain, to maintain homeostatic balance. the brain is a target of stress, and the hippocampus is the first brain reg...

recognized as a reliable tool for assessing the hypothalamus-pituitary-adrenal (hpa) axis, measurement of salivary cortisol plays an important role in both the clinical and research settings. to establish a normative data, which forms the basis for the usage of this valuable parameter, we gathered 8:00 h saliva samples from 94 healthy individuals aged 6-14 years. cortisol levels were measured b...

Introduction: Glucocorticoids are considered the cornerstone of the induction phase in all treatment protocols of acute lymphoblastic leukemia (ALL). Among the adverse effects of high-dose glucocorticoid treatment, adrenal insufficiency is secondary to suppression of the hypothalamic-pituitary-adrenal (HPA) axis. This drawback of exogenous steroid therapy gains a contemporary particular relevan...

results all variables reached a peak at 1 minute post-jump. salivary alpha-amylase, galvanic skin responses and heart rate did not return to basal value at 90 minutes post-jump, while cortisol returned to basal value at 90 minutes post-jump. conclusions this evidence indicates that parachute jumping is accompanied by a dissociation of sns and hpa response patterns in novice parachutists, showin...

This study investigated adrenocortical activity in response to different challenging and positive affect emotional contexts in child-mother dyads, as function of attachment security (children's secure base behaviors and mothers' attachment representations). Fifty-one children ranging in age from 18 to 26 months and their mothers participated in this study. Secure children showed significant inc...