Objective: Insulin resistance (IR) is the major cause in Type 2 diabetes mellitus (T2DM). Expression of some miRNAs can be changed in response to a drug treatment for IR, and used as the biomarker in IR. This study set out to determine the effect of cinnamon extract (cinnamaldehyde) on some miRNAs expression in IR adipocytes. Materials and Methods: In this In-vitro study the 3T3L1 cells were e...

Background: Norepinephrine plays a trophic role in the control of cell replication and differentiation in target cells that express adrenergic receptors. Methods: In this study, we have tested the influence of infraphysiological, physiological and supraphysiological concentrations (0.0001 nM, 1 nM, 10000 nM) of human norepinephrine on the proliferation of breast cancer cells (human breast adeno...

background: norepinephrine plays a trophic role in the control of cell replication and differentiation in target cells that express adrenergic receptors. methods: in this study, we have tested the influence of infraphysiological, physiological and supraphysiological concentrations (0.0001 nm, 1 nm, 10000 nm) of human norepinephrine on the proliferation of breast cancer cells (human breast adeno...

lipoma, a benign tumor of adipose tissue is one of the most common benign neoplasms of the body. however, its occurrence in oral cavity is very rare. it accounts for 1 to 4% of benign neoplasms of mouth affecting predominantly the buccal mucosa, floor of mouth and tongue. we report three cases of intraoral lipoma, two in buccal mucosa and one in labial mucosa. an excisional biopsy was performed...

lipomas are rare benign soft tissue mesenchymal neoplasms in the oral cavity, representing 1% of all benign oral tumors. fibrolipoma (fl), an uncommon, histological variant of the classic lipoma, mostly affects the buccal mucosa. very few cases of fl have been reported in the english literature. to the best of our knowledge a review of the english literature showed 33 cases of fl affecting the ...

cancer cell-stromal cell interaction plays a crucial role in the growth and invasion of tumor cells of various organs. it has been recently suggested that adipocytes and preadipocytes, two specific types of stromal cells, affect the biological behavior of variety of breast cancer cell lines. in spite of few investigations, there is a controversy in the literatures about the effects of adipocyte...

 Objective: In obesity, chronic low grade inflammation, created by induction of pro-inflammatory markers, causes adipocyte dysfunction in adipose tissue. Adipocytes dysfunction is associated with various diseases including insulin resistance and obesity. In obesity, inflammatory factors such as osteopontin (OPN), angiopoietin-like protein 2 (Angptl2) and transforming growth factor-β (TGF-β) are...

background : many types of cancer cells require a supply of fatty acids (fa) for growth and survival, lpl, in the presence of triglyceride-rich lipoproteins, accelerates the growth of these cells. recent evidence shows that lpl plays important roles in inflammation and obesity, implies that it is an appropriate general target for chemo preventive and chemotherapeutic agents. thus, we reported l...

Obesity is recognized as a severe threat to overall human health and associated with type 2 diabetes mellitus, dyslipidemia, hypertension, cardiovascular diseases. Abnormal expansion of white adipose tissue involves increasing the existing adipocytes' cell size or number through differentiation new adipocytes. Adipogenesis process proliferation adipocyte precursor cells in mature As key determi...