A method has recently been described for measuring the mutual adhesiveness of epithelial cells (3). It was found that cells of squamous cell carcinomas adhered to each other less strongly than did homologous normal epithelial cells. As the cause of this reduction in adhesiveness is not known, it seemed important to seek for an explanation of adhesiveness in normal cclls, and to learn what chang...

A marked increase in platelet adhesiveness was shown to occur within four hours of operation. Postoperative red cells produced greater adhesiveness in platelets from a common pool than did preoperative red cells. A greater increase in platelet adhesiveness was observed following operation with the whole blood technique than when exogenous adenosine diphosphate was added to platelet-rich plasma....

Platelet adhesiveness has been measured in citrated whole blood and in platelet-rich plasma obtained from normal subjects, splenectomized patients, and from patients in whom the diagnosis of recurrent venous thrombosis had been made. The duration of centrifugation used in the preparation of platelet-rich plasma was found to have a profound effect on the measurement of platelet adhesiveness beca...

Nathanson and Savitsky (1952) were the first to study platelet adhesiveness in patients suffering from multiple sclerosis (60 in all). Increased adhesiveness was found in the groups of patients with acute exacerbations or a fluctuating course: the average 'adhesive index' for the stationary group was within the normal range. More recently two preliminary communications were published on the sam...

Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is elevated in hypercholesterolemia. This study was designed to determine the role of ADMA in the increased mononuclear cell adhesiveness observed in human hypercholesterolemia. In patient studies, plasma ADMA levels were determined by high-performance liquid chromatography. Functional mononuclear leukocyte ad...

Thirty-one subjects from three families affected by Von Willebrand's disease have been investigated with the following tests: Ivy's bleeding time; platelet adhesiveness according to Salzman; two-stage factor VIII assay. Twelve patients have a complete form of the disease, i.e., a prolonged bleeding time with low platelet adhesiveness, and a reduced factor VIII level. Eight subjects have an isol...

Platelet adhesiveness was measured in vitro in a group of patients with ischaemic heart disease and in a group of matched healthy subjects using either 1% EDTA or 3.8% sodium citrate as anticoagulant. When sodium citrate was used platelet adhesiveness was significantly greater in the group with ischaemic heart disease. However, no difference was found when EDTA was used. In both groups platelet...

Platelet adhesiveness was measured in patients undergoing operation. With the rotating bulb technique adhesiveness increased steadily to the sixth and ninth days following surgery. The glass bead filter technique demonstrated a marked increase in platelet adhesiveness on the day following operation.