AdeR-AdeS is a two-component regulatory system, which controls expression of the adeABC efflux pump involved in Acinetobacter baumannii multidrug resistance. AdeR is a response regulator consisting of an N-terminal receiver domain and a C-terminal DNA-binding-domain. AdeR binds to a direct-repeat DNA in the intercistronic region between adeR and adeABC. We demonstrate a markedly high affinity b...

We study stability properties and truncation errors of the finite-volume ADER schemes on structured meshes as applied to the linear advection equation with constant coefficients in one-, twoand threespatial dimensions. Stability of linear ADER schemes is analysed by means of the von Neumann method. For nonlinear schemes, we deduce the stability region from numerical experiments. The truncation ...

The Gi-coupled adenine receptor (AdeR) binds adenine with high affinity and potentially reduces cellular cAMP levels. Since cAMP is an important second messenger in the renal transport of water and solutes, we localized AdeR in the rat kidney. Real-time RT-PCR showed higher relative expression of AdeR mRNA in the cortex and outer medulla compared with the inner medulla. Immunoblots using a pept...

ADER schemes are recent finite volume methods for hyperbolic conservation laws, which can be viewed as generalizations of the classical first order Godunov method to arbitrary high orders. In the ADER approach, high order polynomial reconstruction from cell averages is combined with high order flux evaluation, where the latter is done by solving generalized Riemann problems across cell interfac...

Objective To compare the relative human abuse potential of intact and manipulated morphine abuse-deterrent, extended-release injection-molded tablets (morphine-ADER-IMT) with that of marketed morphine sulfate ER tablets. Methods This randomized, double-blind, triple-dummy, active- and placebo-controlled, 4-way crossover, single-center study included adult volunteers who were experienced, nond...

The ADER approach is the extended Godunov-type schemes[1] which construct nonoscillatory explicit one-step schemes with very high order of accuracy in space and time by solving the DRPs (derivative Riemann problems). The ADER approach has been developed from the schemes for the linear scalar hyperbolic equations[2] to those for nonlinear multi-dimensional systems[3,4,5,6,7], and further to thos...

In this paper we carry out the extension of the ADER approach to multidimensional non-linear systems of conservation laws. We implement non-linear schemes of up to fourth order of accuracy in both time and space. Numerical results for the compressible Euler equations illustrate the very high order of accuracy and non-oscillatory properties of the new schemes. Compared to the state-of-art finite...

In this paper, we develop a fully discrete entropy preserving ADER-Discontinuous Galerkin (ADER-DG) method. To obtain desired result, equip the space part of method with correction terms that balance production in space, inspired by work Abgrall. Whereas for time-discretization apply relaxation approach introduced Ketcheson allows to modify timestep preserve machine precision. Up our knowledge,...

We present results of thorough benchmarking of an arbitrary high-order derivative discontinuous Galerkin (ADER-DG) method on unstructured meshes for advanced earthquake dynamic rupture problems. We verify the method by comparison to well-established numerical methods in a series of verification exercises, including dipping and branching fault geometries, heterogeneous initial conditions, bimate...