نتایج جستجو برای: adenylyl cyclase

تعداد نتایج: 17672  

احمدی, مجید, قوجق, دردی,

 Adenylyl cyclase is a membrane-bound enzyme that catalyzes the conversion of ATP to cAMP. The inhibition of adenylyl cyclase was carried out by measuring the ability of the macrophage chemotactic protein-1 to inhibit the forskolin-induced enzyme activity. Measurement of adenylyl cyclase activity was performed according to the procedure described by Wiegn.  Adenylyl cyclase activity in the pres...

Journal: :iranian journal of allergy, asthma and immunology 0
durdi qujeq majid ahmadi

adenylyl cyclase is a membrane-bound enzyme that catalyzes the conversion of atp to camp. the inhibition of adenylyl cyclase was carried out by measuring the ability of the macrophage chemotactic protein-1 to inhibit the torskolin-induced enzyme activity. adenylyl cyclase activity in the presenc of macrophage chemotactic protein-1 was decreased compared to that in controls [2.11+/-0.15 (mean +/...

Journal: :IUPHAR/BPS guide to pharmacology CITE 2023

Adenylyl cyclase, E.C. 4.6.1.1, converts ATP to cyclic AMP and pyrophosphate. Mammalian membrane-delimited adenylyl cyclases (nomenclature as approved by the NC-IUPHAR Subcommittee on [11]) are typically made up of two clusters six TM domains separating intracellular, overlapping catalytic that target for nonselective activators Gαs (the stimulatory G protein α subunit) forskolin (except AC9, [...

Journal: :Wiley Interdisciplinary Reviews: Computational Molecular Science 2023

The cover image is based on the Focus Article Multiscale molecular simulations to investigate adenylyl cyclase-based signaling in brain by Siri C. van Keulen et al., https://doi.org/10.1002/wcms.1623. Image Credit: F. Colizzi

Journal: :iranian journal of allergy, asthma and immunology 0
yajuan wang zhejiang respiratory drugs research laboratory of state food and drug administration of china, college of medicine, zhejiang university, hangzhou 310058, china and the center of function experiment, anhui college of traditional chinese medicine, hefei, 230038, china yali jiang zhejiang respiratory drugs research laboratory of state food and drug administration of china, college of medicine, zhejiang university, hangzhou 310058, china huifang tang zhejiang respiratory drugs research laboratory of state food and drug administration of china, college of medicine, zhejiang university, hangzhou 310058, china xuefeng wang zhejiang respiratory drugs research laboratory of state food and drug administration of china, college of medicine, zhejiang university, hangzhou 310058, china chunzhen zhao zhejiang respiratory drugs research laboratory of state food and drug administration of china, college of medicine, zhejiang university, hangzhou 310058, china jiqiang chen zhejiang respiratory drugs research laboratory of state food and drug administration of china, college of medicine, zhejiang university, hangzhou 310058, china

phosphodiesterases  (pde)  hydrolyse intracellular camp  and  cgmp  to  inactive  5’ monophosphates. decreased level of camp is involved in the pathogenesis of asthma. we and others have shown that phosphodiesterases were upregulated in the lung of allergic rats, and bacilli calmette-guérin (bcg) induced the production of camp in vitro. however, it is unclear how bcg’s effect asthma and whether...

Journal: :Journal of Cellular Physiology 2023

Front Cover: The cover image is based on the Research Article Proper phosphorylation of septin 12 regulates 4 and soluble adenylyl cyclase expression to induce sperm capacitation by Han-Yu Wang et al., https://doi.org/10.1002/jcp.30951.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1989
D Young M Riggs J Field A Vojtek D Broek M Wigler

We cloned the adenylyl cyclase gene from the fission yeast Schizosaccharomyces pombe using low-stringency hybridization to the Saccharomyces cerevisiae adenylyl cyclase gene. The Sc. pombe gene encodes a 1692-amino acid-residue protein. The identity of this gene was confirmed by studies of its expression in Sa. cerevisiae. Expression of the carboxyl-terminal region of the Sc. pombe adenylyl cyc...

Journal: :The Journal of clinical endocrinology and metabolism 2001
M Côté G Guillon M D Payet N Gallo-Payet

The aim of the present study was to identify which adenylyl cyclase isoforms were expressed in the human adrenal gland and to determine which isoform(s) may be coupled to ACTH action. Our results indicate that, in both glomerulosa and fasciculata zones, adenylyl cyclase 1 was detected in cells at the membrane level, adenylyl cyclases 3 and 2 in both the cytoplasm and the plasma membrane, wherea...

Journal: :Circulation 2002

Journal: :Molecular pharmacology 2006
Hui Zhao Horace H Loh P Y Law

Long-term opioid agonist treatment results in adenylyl cyclase superactivation. A recent "RAVE" theory implicates a direct correlation between the ability of agonist to induce receptor internalization and the magnitude of adenylyl cyclase superactivation. We decided to test such a theory by examining the adenylyl cyclase superactivation after long-term activation of mu-opioid receptor (MOR) in ...

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