نتایج جستجو برای: adenylate cyclase toxin

تعداد نتایج: 69554  

Journal: :jundishapur journal of microbiology 0
seyed abdolmajid khosravani department of microbiology, yasuj university of medical sciences, yasuj, ir iran john coote department of microbiology, university of glasgow, glasgow, uk roger parton department of microbiology, university of glasgow, glasgow, uk seyed mohammad ali mansourian department of microbiology, yasuj university of medical sciences, yasuj, ir iran seyed abdolrahim rezaee immunology research centre, medical school, mashhad university of medical sciences, mashhad, ir iran; department of immunovirology, mashhad university of medical sciences, mashhad, ir iran. tel: +98-9155148304

background adenylate cyclase toxin (cyaa) is an important virulence factor of bordetella pertussis, the causative agent of whooping cough, and a potential component of acellular pertussis vaccine. objectives in the present study the impact of invasive cyaa on oxidative activities of phagocytes was compared with the other form of this molecule to investigate the activity of different parts of mo...

Journal: :Infection and immunity 2000
C L Weingart P S Mobberley-Schuman E L Hewlett M C Gray A A Weiss

A previous study showed that opsonization with human immune serum could either promote or antagonize phagocytosis of Bordetella pertussis by human neutrophils depending on whether the bacteria expressed adenylate cyclase toxin. Opsonization of the wild-type strain inhibited phagocytosis relative to unopsonized controls. In contrast, mutants lacking adenylate cyclase toxin were efficiently phago...

Journal: :Molecular pharmacology 1986
C K Mickevicius J K Harrison M E Gnegy

The effect of cholera toxin on activation of adenylate cyclase by the endogenous Ca2+-binding protein, calmodulin, GTP, dopamine, and forskolin was investigated in bovine striatum. Adenylate cyclase activity was measured in washed membrane fractions prepared from homogenates that had been preincubated with cholera toxin. Pretreatment of striatal membranes with cholera toxin increased the respon...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1977
D Cassel Z Selinger

Treatment of turkey erthrocyte membranes with cholera toxin caused an enhancement of the basal and catecholamine-stimulated adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activities. Both of these activities required the presence of GTP. The toxin effect on the adenylate cyclase activity concided with an inhibition of the catecholamine-stimulated guanosinetriphosphatase act...

2017
B. Ewa Snaar-Jagalska Peter J.M. Van Haastert

cAMP binds to surface receptors of Dictyostelium discoideum cells, transducing the signal to adenylate cyclase, guanylate cyclase and to chemotaxis. The activation of adenylate cyclase is maximal after 1 min and then declines to basal levels due to desensitization, which is composed of two components: a rapidly reversible adaptation process, and a slowly reversible down-regulation of cAMP recep...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1975
V Bennett E O'Keefe P Cuatrecasaş

Rat liver membrane adenylate cyclase (EC 4.6.1.1) that has been stimulated more than 10-fold by cholera toxin (choleragen) has a 3-fold greater sensitivity to stimulation by glucagon. Choleragen similarly increases the sensitivity of cyclase to other peptide (ACTH, vasoactive intestinal polypeptide) and nonpeptide (catecholamines) hormones in this and other tissues. The rate of 125I-labeled glu...

Journal: :The Journal of biological chemistry 1981
S E Sadler J L Maller

Previous studies have shown that ripe Xenopus 00cytes, 1.4 mm in diameter and suitable for microinjection, undergo meiotic cell division in response to progesterone by a mechanism involving a decrease in the level of CAMP. In order to investigate the mechanism by which the level of CAMP is reduced by progesterone treatment, adenylate cyclase activity was measured in manually dissected plasma me...

Journal: :The Journal of biological chemistry 1986
P D Wilson B S Dixon M A Dillingham J A Garcia-Sainz R J Anderson

The biochemical mechanisms of adenylate cyclase desensitization in arginine vasopressin-responsive epithelial cells remain unclear. Preincubation of cultured rabbit renal cortical collecting tubular cells with arginine vasopressin leads to a 30-100% decline in arginine vasopressin-stimulated adenylate cyclase activity. This loss of adenylate cyclase activity is time- and arginine vasopressin co...

Journal: :The Journal of clinical investigation 1975
J Flores G W Sharp

Similarities exist between the properties of adenylate cyclase after stimulation by cholera toxin and after stimulation by guanylylimidodiphosphate (Gpp-(NH)p). Thus a strong stimulation is achieved by both agents, the stimulation is essentially irreversible, the action of certain hormones is enhanced and the enzyme can be solublized with Lubrol PX in the activated state. Because of these simil...

Journal: :The Biochemical journal 1991
F R McKenzie G Milligan

Cholera toxin treatment (up to 1 microgram/ml, 16 h) of neuroblastoma x glioma hybrid NG108-15 cells produced a decrease of some 35% in both delta opioid receptor-mediated stimulation of high-affinity GTPase activity and inhibition of forskolin-amplified adenylate cyclase. Coincident with these decreases was a down-regulation of some 35% in the delta opioid receptor population. A similar patter...

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