The term mitral valve prolapse (MVP) is used for a particular subset of patients with hyperadrenergic dysautonomia. It occurs when part of a leaflet or both leaflets of the mitral valve extend above the plane of the atrioventricular junction during ventricular systole. The adenylate cyclase activity in MVP dys-autonomia was studied by extraction of enzyme from the erythrocytes from 62 norma...

the term mitral valve prolapse (mvp) is used for a particular subset of patients with hyperadrenergic dysautonomia. it occurs when part of a leaflet or both leaflets of the mitral valve extend above the plane of the atrioventricular junction during ventricular systole. the adenylate cyclase activity in mvp dys-autonomia was studied by extraction of enzyme from the erythrocytes from 62 normal su...

background adenylate cyclase toxin (cyaa) is an important virulence factor of bordetella pertussis, the causative agent of whooping cough, and a potential component of acellular pertussis vaccine. objectives in the present study the impact of invasive cyaa on oxidative activities of phagocytes was compared with the other form of this molecule to investigate the activity of different parts of mo...

The purpose of this work is to evaluate the effect of thuringiensin on the adenylate cyclase activity in rat cerebral cortex. The cyclic adenosine 3'5'-monophosphate (cAMP) levels were shown to be dose-dependently elevated 17-450% or 54-377% by thuringiensin at concentrations of 10 microM-100 mM or 0.5-4 mM, due to the activation of basal adenylate cyclase activity of rat cerebral cortical memb...

Adenylate cyclase activity in bovine retina is highly responsive to Ca2+ and the endogenous Ca2+-binding protein, calmodulin (CaM). CaM stimulated adenylate cyclase activity in washed particulate fractions of bovine retina by 6.6-fold in a Ca2+-dependent manner. Activation of adenylate cyclase activity by CaM was maximal at 0.12 microM free Ca2+. The apparent Ka for calmodulin stimulation of ad...

L-Histidine and imidazole (the histidine side chain) significantly increase cAMP accumulation in intact LLC-PK1 cells. This effect is completely inhibited by isobutylmethylxanthine (IBMX). Histidine and imidazole stimulate cAMP phosphodiesterase activity in soluble and membrane fractions of LLC-PK1 cells suggesting that the IBMX-sensitive effect of these agents to stimulate cAMP formation is no...

Previous studies using calmodulin-Sepharose affinity chromatography have suggested that bovine brain may contain a mixture of calmodulin-sensitive and -insensitive adenylate cyclase activities (Wescott, K. R., La Porte, D. C., and Storm, D. R. (1979) Proc. Natl. Acad. Sci. U.S.A. 82, 3086-3090). In this study, mice were immunized with a purified preparation of the calmodulin-sensitive adenylate...

Adenylate cyclase activity has been examined in adrenocortical tumor cell cultures which exhibit adrenocorticotropic hormone (ACTH)-stimulated steroidogenesis (Y-l) and in mutant adrenal cell lines which are insensitive to added ACTH (Y-6 and OS3). Adenylate cyclase activity is stimulated by ACTH in Y-l cells but not in Y-6 or OS3 cells. The absence of hormone-sensitive adenylate cyclase activi...

The effect of adenylate cyclase activation on the in vitro contractures of control and malignant hyperpyrexia susceptible (MHS) porcine muscle was investigated. While fluoride and molybdate ions potentiated drug-induced contractures in control muscle, other activators of adenylate cyclase (forskolin and noradrenaline) did not. Furthermore, fluoride and molybdate had no effect on MHS skeletal mu...

Pretreatment of intact cultured WI-38 fibroblasts with either prostaglandin E1 (PGEI) or epinephrine progressively desensitized adenylate cyclase. PGEl pretreatment reduced basal, guanyl-5’-yl imidodiphosphate (GPP(NH)P), epinephrineand PGEl-stimulated adenylate cyclase activities with no effect on the fold stimulation of either PGEI or epinephrine. In contrast, epinephrine pretreatment desensi...