نتایج جستجو برای: adenoviral vector

تعداد نتایج: 201214  

Journal: :iranian journal of virology 0
f rezaei gastroenterohepatology research center, shiraz university of medical sciences, shiraz, iran sy hosseini gastroenterohepatology research center, shiraz university of medical sciences, shiraz, iran mh karimi shiraz transplant research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran a pakneiat gastroenterohepatology research center, shiraz university of medical sciences, shiraz, iran b geramizadeh shiraz transplant research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran mr fattahi gastroenterohepatology

background and aims: adenovector gene transfer induces inflammatory response that finally leads to vector removal from delivered site. the effect of hydrodynamic pre-injection on adenovector mediated liver inflammation remained elusive. materials and methods: different mice groups were pre-treated by hydrodynamic saline, dexamethasone or nothing prior to adeno-luciferase administration. their s...

Meshkat Mesh Poortavakol, Mohammad Sayyadi, Saeed Hassani,

The common reported adverse impacts of COVID-19 vaccination include the injection site’s local reaction followed by various non-specific flu-like symptoms. Nevertheless, uncommon cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) and cerebral venous sinus thrombosis (CVST) following viral vector vaccines (ChAdOx1 nCoV-19 vaccine, Ad26.COV2 vaccine) have been reported. This liter...

Alireza Zamani, Masoud Sabouri Ghannad,

Adenoviruses are used extensively to deliver genes into mammalian cells, particularly where there is a requirement for high-level expression of transgene products in cultured cells, or for use as recombinant viral vaccines or in gene therapy. In spite of their usefulness, the construction of adenoviral vectors (AdV) is a cumbersome and lengthy process that is not readily amenable to the generat...

Journal: :iranian biomedical journal 0
علیرضا زمانی alireza zamani مسعود صبوری قناد masoud sabouri ghannad

adenoviruses are used extensively to deliver genes into mammalian cells, particularly where there is a requirement for high-level expression of transgene products in cultured cells, or for use as recombinant viral vaccines or in gene therapy. in spite of their usefulness, the construction of adenoviral vectors (adv) is a cumbersome and lengthy process that is not readily amenable to the generat...

Journal: :Circulation 2004
Shan Wen Shannon Graf Philip G Massey David A Dichek

BACKGROUND Adenoviral vectors are the most widely used agents for vascular gene transfer. However, the utility of adenoviral vectors for vascular gene transfer is limited by brevity of expression and by the induction of a significant host inflammatory response. Third-generation or "helper-dependent" adenoviral vectors have achieved prolonged recombinant gene expression in liver and muscle with ...

2012
Maria Abildgaard Steffensen Benjamin Anderschou Holbech Jensen Peter Johannes Holst Maria Rosaria Bassi Jan Pravsgaard Christensen Allan Randrup Thomsen

Adenoviral vectors have shown a great potential for vaccine development due to their inherent ability to induce potent and protective CD8 T-cell responses. However, a critical issue regarding the use of these vectors is the existence of inhibitory immunity against the most commonly used Ad5 vector in a large part of the human population. We have recently developed an improved adenoviral vaccine...

Journal: :Journal of immunology 2003
Arguinaldo R Pinto Julie C Fitzgerald Wynetta Giles-Davis Guang Ping Gao James M Wilson Hildegund C J Ertl

E1-deleted adenoviral recombinants most commonly based on the human serotype 5 (AdHu5) have been shown thus far to induce unsurpassed transgene product-specific CD8(+) T cell responses. A large percentage of the adult human population carries neutralizing Abs due to natural exposures to AdHu5 virus. To circumvent reduction of the efficacy of adenovirus (Ad) vector-based vaccines by neutralizing...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2004
Lisa M Schwiebert

THE STUDY by van Heeckeren and colleagues, one of the current articles in focus (Ref. 20, see p. L717 in this issue), addresses the question of whether adenoviral delivery of cystic fibrosis transmembrane conductance regulator (CFTR) to the cystic fibrosis airways attenuates inflammation and mortality associated with a chronic bacterial infection. This is an intriguing question because adenovir...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1999
K Kasono J L Blackwell J T Douglas I Dmitriev T V Strong P Reynolds D A Kropf W R Carroll G E Peters R P Bucy D T Curiel V Krasnykh

In vivo cancer gene therapy approaches for squamous cell carcinoma of the head and neck (SCCHN) based on adenoviral vector-mediated gene delivery have been limited by the suboptimal efficacy of gene transfer to tumor cells. We hypothesized that this issue was due to deficiency of the primary adenoviral receptor, the coxsackie-adenovirus receptor (CAR), on the tumor targets. Studies of CAR level...

2015
Hao Chen Dongyang Wang Ruiting Xia Qinwen Mao Haibin Xia

BACKGROUND One of the most commonly used vectors for gene therapy is the adenoviral vector; its ability to tightly regulate transgene expression is critical for optimizing therapeutic outcomes. The tetracycline-regulated system (especially the Tet-On system) for gene expression is one of the most valuable tools for controlling gene expression. The major problem of an adenoviral vector carrying ...

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