adenosine deaminase is an aminohydrolase (ec 3.5.4.4) which participates in the purine metabolism where it degrades either adenosine or 2'-deoxyadenosine producing inosine or 2'-deoxyinosine, respectively. the enzyme contains a parallel alpha/beta -barrel motif with eight central beta strands and eight peripheral alpha helices. ada is located both in the cytosol and on the cell membrane. since ...

Introduction Myocardial perfusion cardiac magnetic resonance imaging (MRI) is established as a high sensitive procedure to diagnose coronary artery disease (CAD). In practice exercise electrocardigram (XECG) is widely used as non invasive method to detect relevant coronary stenosis (>50%). The aim of this study was to investigate the diagnostic perfomance of adenosin stress 3-Tesla cardiac MRI ...

Strains with 1-aminocyclopropane-1-carboxylate (ACC) deaminase activity can cause plant growth on stress condition. In the presence of bacteria with the ability of ACC deaminase production in the rhizosphere, it is possible to convert the ethylene precursor (ACC) to α-ketobutyrate  and ammonium, reducing the ethylene levels in host plants. In order to measure the power and level of A...

Two strategies for the synthesis of the ATP (adenosine triphosphate) analogue ApppI [1-adenosin-5'-yl 3-(3-methylbut-3-enyl)triphosphoric acid diester] (1) are described. ApppI is an active metabolite of the mevalonate pathway and thus is of major biological significance. Chemically synthezised ApppI was purified by using triethylammonium bicarbonate as the counter ion in ion-pair chromatograph...

chronic obstructive pulmonary disease (copd) has been defined by the global initiative for chronic obstructive lung disease (gold), as a disease state characterized by airflow limitation which is not fully reversible. copd consists of emphysema which is the destruction and inflammation of the lung alveoli. adenosine deaminase (ada, e.c.3.5.4.4) converts adenosine to inosine. there are two isoen...

one of the important mechanisms utilized by the plant growth promoting rhizobacteria (pgpr) is lowering of ethylene levels by the 1-aminocyclopropane-1-carboxylic acid (acc) deaminase enzyme. the mechanism facilitates plant growth and development in the stress conditions. pgpr containing acc deaminase can promote plant growth under stress and overcome the harmful effects. the study aimed to scr...

The aim of the article is to describe the principal findings among patients with M.tuberculosis and M. bovis CNS infection. Mycobacterium tuberculosis is one of the most common infectious agents that cause death and neurological sequelae around the world. Most of the complications of CNS TB can be attributed to a delay in the diagnosis. Unfortunately, there are no specific diagnostic tools to s...

Methods In 42 HLHS patients (6.0 ±2.3 yrs) and 14 healthy volunteers (6.8 ±3.9 yrs), MRI first-pass perfusion (0.03 mmol/kg Gd-DTPA; TR/TE/a=2.6/1.1/20°) and late gadolinium enhancement (LGE) imaging was performed using a 3 Tesla scanner (Philips Achieva). Quantitative myocardial blood flow at rest and stress (Adenosin 140 mcg/kg/min) was calculated in 4 anatomical RV segments per slice using a...