abstract background leukemia is the most prevalent childhood cancer and acute lymphoblastic leukemia (all) constitutes 75% of all cases. the most frequent presenting symptoms are fever, weight loss and pallor. early detection of clinical symptoms positively affects timely diagnosis. the objectives of the present study were to assess frequency of presenting symptoms, laboratory data, immune phen...

it has recently been shown that ror1, a member of the receptor tyrosine kinase family, is overexpressed in leukemic b cells of chronic lymphocytic leukemia (cll) and a subset of acute lymphoblastic leukemia (all). in this comparative study the expression profile of ror1 mrna was investigated in iranian patients with cll and acute myelogenous leukemia (aml) and the results were compared with tho...

background: mature t/ nk-cell neoplasms are a rare group of disorders and their presentation as leukemia is even rarer. most of the previous studies have focused on mature b-cell lineage leukemias and there is a paucity of data on mature t/nk-cell lineage leukemias. we, therefore, planned this study to analyze their spectrum, frequency, morphology and immunophenotypic features. methods: all cas...

we presents an infant with several indurated plaques and nodules scattered on her body. she was brought to the hospital because of fever, runny nose and cough from one month ago. during the examination and investigation the plaques and nodules grabbed the attention of the clinicians and the skin biopsy and other lab works revealed the diagnosis of congenital leukemia.

background: environment of basrah is seriously contaminated with chemical leukomogens as a result of recent military conflicts. many studies in the past few years have reported an increase in the incidence of leukemia in basrah. this study was designed to study the risk and pattern of childhood leukemia in basrah, iraq, from 2003 to 2007.materials and methods: this hospital-based cancer registr...

infection is one of the cardinal difficulties in the children with acute leukemia and is the leading cause of mortality among them. the prevalence of infection in these patients has several reasons including usage of cytotoxic agents, corticosteriods, broad consumption of antibiotics, duration of confinement in hospital, defective of cellular and humoral immunity, neutropenia and dysfunction of...

Myeloid/lymphoid neoplasms with FGFR1 rearrangement (MLN-FGFR1) comprise a heterogeneous group of that can present as myeloproliferative neoplasm, myelodysplastic/myeloproliferative acute myeloid leukemia, T or B lymphoblastic leukemia/lymphoma, mixed phenotype leukemia. The overall outcome these is poor, and patients often show cytogenetic evolution gain additional chromosomal abnormalities le...

acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. the conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. it has been rarely reported in the literature. in leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. herein, we rep...

midface bones are an unusual site for primary presentation and relapse in acute lymphoblastic leukemia. herein, we describe a case of acute pre b cell lymphoblastic leukemia with leukemic infiltration of maxilla and bone marrow involvement. at the time of relapse, the patient presented again with maxilla involvement and the phenotype changed to biphenotypic lymphoblastic leukemia. our case sugg...

Background: Environment of Basrah is seriously contaminated with chemical leukomogens as a result of recent military conflicts. Many studies in the past few years have reported an increase in the incidence of leukemia in Basrah. This study was designed to study the risk and pattern of childhood leukemia in Basrah, Iraq, from 2003 to 2007.Materials and Methods: This hospital-based cancer registr...