though intravenous (iv) magnesium sulphate (mgs04) has additive effect to beta-2 agonists, its additive benefit in face of combination therapy with beta-2-agonists and ipratropium (standard therapy of severe acute exacerbation of asthma) remains unaddressed. the aim of this investigation was to evaluate the role of iv mgso4 when used as an adjunct to standard therapy of severe exacerbations of ...

background: about 5–10% of patients with asthma suffer from poorly-controlled disease despite corticosteroid (cs) therapy. methods: 21 severe and 30 mild asthma patients were recruited and underwent collection of blood sample. we determined whether there were any differences in inflammatory biomarkers between severe and mild asthma patients or not.results: levels of interleukin-8 (il-8) and int...

Introduction Acute severe asthma is one of the most common causes of visits to hospital emergency departments worldwide and accounts for the greater part of the economic and healthcare burden of the disease.1 Failure to appreciate the severity, inadequate emergency treatment, and delay in referral may lead to increased mortality and morbidity.2 Asthma is the most common respiratory emergency in...

Despite the continuous improvement in the therapeutic strategy for asthma, there is still a subset of asthma exacerbations—severe acute asthma—that still requires access to the emergency department and, eventually, hospitalization.1-3 It’s estimated that approximately 5–10% of asthmatic patients experience a severe acute asthma episode in a given year, and that there are approximately 2 million...