splenic infarction occurs due to occlusion of splenic vessels that leads to splenic tissue ischemia and necrosis. there are several reports regarding splenic infarction in patients with acute myelogenous leukemia (aml). herein, we report a case of acute promyelocytic anemia (aml-m3) who presented with abdominal pain and splenic infarction.

Splenic infarction occurs due to occlusion of splenic vessels that leads to splenic tissue ischemia and necrosis. There are several reports regarding splenic infarction in patients with acute myelogenous leukemia (AML). Herein, we report a case of acute promyelocytic anemia (AML-M3) who presented with abdominal pain and splenic infarction.

Acute promyelocytic leukemia is potentially a highly curable type of leukemia that usually presents with pancytopenia, coagulopathies and bleeding. We describe a case of an unusual presentation of acute promyelocytic leukemia. A 53 year-old male was admitted complaining of pain and weakness in his legs. He presented at examination a spastic paraparesis with a sensitive level at the eighth thora...

Aplastic anemia (AA) is a hematological disorder presenting with pancytopenia in peripheral blood and hypocellularity in bone marrow. AA patients with immunosuppressive therapy and granulocyte colony-stimulating factor treatment have a risk of development of acute leukemia including acute myeloid leukemia (M0, M1, M2, M4, M5, M6) and acute lymphoblastic leukemia. However, AA with transformation...

arsenic trioxide (ato) has been reported to induce apoptosis in leukemic cells of acute promyelo-cytic leukemia (apl) patients through different pathways. however, the exact mechanism of ato-induced apoptosis is not yet clear. co stimulation of death receptors cd30 and tumor necrosis factor receptor type one (tnfr-i) is one of the postulated mechanisms.in the present study we aimed to evaluate ...

introduction: the telomeric dna together with its associated  proteins protects the chromosome ends from degradation or aberrant recombination. telomerase and telomere are closely associated with  development of cancers. in this study we aim to investigate the significance of telomerase activity (ta) and telomere length (tl) in patients with acute promyelocytic leukemia (apl). methods: peripher...

background: the secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (pml-rara) fusion gene may contribute to the acute promyelocytic leukemogenesis. chromosomal alterations and mutation of flt3 (fms-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. however, the prognostic significance of flt3 mutat...

introduction: fournier's gangrene or necrotizing fasciitis of external genitalia is a medical emergency. it was reported in cases of acute promyelocytic leukemia (apl) before and during induction therapy with all- trans retinoic acid (atra).we present a case of apl that developed fournier's gangrene   during atra therapy.

introduction: the secondary genetic changes other than the pml-rara fusion gene may contribute to the acute promyelocytic leukemogenesis. chromosomal alterations and mutation of flt3 tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia (aml). however, the prognostic significance of flt3 mutations in acute promyelocytic leukemia (apl) is not firmly established....

Background: Arsenic trioxide is a chemical compound that has been used as treatment for various diseases. Despite being potentially toxic, this therapy to treat Acute Myeloid Leukemia and investigated possible different types of cancer. Objectives: The present review aims describe the use studies reported in literature Trioxide therapeutic agent Leukemia, Promyelocytic Chronic Multiple Myeloma,...