it has recently been shown that ror1, a member of the receptor tyrosine kinase family, is overexpressed in leukemic b cells of chronic lymphocytic leukemia (cll) and a subset of acute lymphoblastic leukemia (all). in this comparative study the expression profile of ror1 mrna was investigated in iranian patients with cll and acute myelogenous leukemia (aml) and the results were compared with tho...

given preliminary evidence of timed, sequential chemotherapy of high dose cytosine arabinoside the current study was initiated to assess the side effects and efficacy of this regimen in patients with newly acute myelocytic leukemia (aml). nineteen adults who referred to hematology-oncology and bone marrow transplantation (bmt) research center of tehran university of medical sciences were enroll...

Tumor cells obtained from leukemia and lymphoma patients were investigated for specific insulin receptors. Using radioactive 125I-labeled insulin, specific insulin binding sites were demonstrated on most acute lymphocytic leukemia (ALL) and acute myelocytic leukemia (AML) cells, including acute promyelocytic leukemia (APL), chronic myelocytic leukemia (CML), and acute monocytic leukemia (AMoL) ...

cellular macromolecular fractions was studied in three human lymphoid cell lines (HR1K, RPM1 8226, and MOLT-4), in four lymphosarcomatous tumors, and in leukemic leukocytes obtained from the peripheral blood of three patients with acute lymphocytic leukemia, six with acute myelocytic leukemia, eight with chronic lympho cytic leukemia, and two with chronic myelocytic leukemia. Specific binding, ...

chromatin-associated DNA-directed DNA polymerase activity, and the soluble RNase-sensitive endogenous DNA polymerase activity were examined in two fibroblast cell lines (WI-38 and WI-38VA13), in thirteen lymphoid cell lines originated from normal persons or from acute lymphocytic leukemia, acute myelocytic leukemia, Burkitt lymphoma, or multiple myeloma patients, and also in cells obtained dire...

Phospholipid-sensitive Ca2+-dependent protein kinase (PL-Ca-PK) and its substrates were investigated in neutrophils from normal subjects and in chronic myelocytic and acute myelocytic leukemic cells from patients with or without treatment for leukemia. PL-Ca-PK and its substrates were found in total particulate fraction of normal neutrophils, but less in cytosol. In leukemic cells from chronic ...

Acute myeloid leukemia is not a single disease but a group of neoplastic disorders. The malignant cells gradually replace, and inhibit the growth and maturation of, normal erythroid, myeloid, and megakaryocytic precursors. Included among the names for this condition are acute myelogenous leukemia, acute myelocytic leukemia, acute myeloid leukemia, acute myeloblastic leukemia, acute granulocytic...

Neutrophil elastase (NE) is a neutrophil‑derived serine proteinase with specificity for a broad range of substrates. NE has been reported to be associated with the pathogenesis of several conditions, particularly that of pulmonary diseases. Previous studies have shown that NE can cleave the pro‑myelocyte ‑ retinoic acid receptor‑alpha chimeric protein and is important for the development of acu...

mycotic infections have been commonly encountered in patients with hematological malignancies. the current study seeks the prevalence of actinomycete infection in patients suffering from blood cells malignancies. a hundred and fifty patients with some kinds of blood cells dyscrasia who underwent the bone marrow aspiration were recruited. in addition to the diagnostic work up, samples were exami...

Background: Acute leukemias comprise a heterogeneous group of diseases characterized by rapid and uncontrolled clonal expansion of progenitor cells of the hematopoietic system. Immunophenotyping helps subclassify acute leukemias into subgroups with prognostic implications. Materials and Methods: This descriptive observational cross-sectional study was performed on 80 newly diagnosed cases of a...