background: acute lymphoblastic leukemia (all) constitutes a heterogeneous group of diseases characterized by abnormal proliferation and accumulation of immature lymphoblasts arrested at various differentiation stages. increasing evidence suggests that chromosomal defects are present in these patients. the aim of this study is to investigate the chromosomal radiosensitivity in a group of all pa...

cellular macromolecular fractions was studied in three human lymphoid cell lines (HR1K, RPM1 8226, and MOLT-4), in four lymphosarcomatous tumors, and in leukemic leukocytes obtained from the peripheral blood of three patients with acute lymphocytic leukemia, six with acute myelocytic leukemia, eight with chronic lympho cytic leukemia, and two with chronic myelocytic leukemia. Specific binding, ...

Breast cancer has become the most frequently diagnosed and leading cause of cancer-related death among women worldwide, overtaking lung cancer. The Present study attempts to investigate use D2 -40 for detection lympho- vascular invasion in node negative breast Additionally lympho-vascular using its association with distant metastasis overall prognosis patient was also explored.

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders characterized by ineffective hematopoiesis and frequent progression to acute myeloid leukemia. Within MDS, 5q- syndrome constitutes a distinct clinical entity characterized by an isolated deletion of the long arm of chromosome 5 (5q-), a relatively good prognosis, and infrequent transformation to acute leukemia. The c...

Background and Objective: Since there are very few studies on the immunodeficiency state of the Iranian survivors of pediatric acute lymphoblastic leukemia (ALL), we conducted this study to determine the prevalence of humoral defects in children with ALL at least one year after completion of chemotherapy. Methods: In this study, antibody titers for mumps, rubeola, rubella, tetanus and diphth...

these patients, in general, have a more aggressive form of disease (2, 28, 29). Most patients have lymphoblasts that lack identifiable surface markers. Thus, the subcategories of acute Iymphocytic leukemia in humans probably repre sent proliferation of different clones of lymphoblasts. There are known differences in glucocorticoid susceptibility among functional subcategories of lymphocytes in ...