Background: Rhabdomyolysis is a clinical syndrome that results in releasing myoglobin content from damaged muscle cells into circulation and often causes acute kidney injury (1). Different mechanisms are considered to be responsible in rhabdomyolysis and renal failure. However, free radical generation is the most important mechanism resulting in kidney injury. Thus, the effect ...

drug induced acute kidney injury (aki) has been implicated in 8% to 60% of all cases of in-hospital aki and as such is a recognized source of significant morbidity and mortality. evaluation of incidence, risk factors, onset time, and outcome of  antibiotics' associated acute kidney injury. during one-year period, all patients who developed acute kidney injury during their hospital stay in the i...

conclusions good knowledges for renal function remain a hallmark of daily practice of the anesthesiologist, considering renal function as an important determinant factor in anesthesia practice. context pre-existing renal dysfunction presents specific features that anesthesiologists must deal with. anesthesia and renal function are connected and can interfere with each other. induced hypotension...

Acute kidney injury causes significant morbidity and mortality in the community and clinic. Various pathologies, including renal and cardiovascular disease, traumatic injury/rhabdomyolysis, sepsis, and nephrotoxicity, that cause acute kidney injury (AKI), induce general or regional decreases in renal blood flow. The ensuing renal hypoxia and ischemia promotes the formation of reactive oxygen sp...

Background and Objective: Due to the importance of acute kidney injury associated in patients with sepsis and the impact of various factors on mortality and hospital stay of these patients, this study was conducted to investigate the clinical features and risk factors for acute kidney injury in patients with sepsis. In addition, we examined whether the severity of acute kidney injury affected c...

OBJECTIVE Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis. METHOD Male adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation - CPL); Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity...

background: the most common clinical indication of aminoglycosides (ag) is the treatment of serious gram?negative infections.the aim of this study was to evaluate plausible effects of atorvastatin on the biomarkers of acute kidney injury (aki) in patients receiving amikacin. materials and methods: in this double?blinded randomized clinical trial, fifty patients (25 in each group) receiving amik...

HIGHLIGHTS Ischemia-reperfusion triggers acute kidney injury due to reactive oxygen species. Quercetin is an antioxidant flavonoid that modulate the Rennin-Angiotensin System. prevents tubular cell death, oxidation, and mitochondrial depolarization. interacts with angiotensin AT1 receptor.

ecstasy (mdma; 3,4-methylenedioxymethylamphetamine) is an illicit drug that has been increasingly abused by young people. its effects include euphoria, enhanced sociability and heightened mental awareness. these come about via the increase of serotonin in both the central nervous system and the sympathetic nervous system. despite the drug’s prevalent abuse, serious or adverse effects are rare. ...

background considering the significant geographical and ethnical differences in pattern of incidence, etiology and outcome of chronic kidney disease (ckd), the present study aimed to assess the etiology and outcome of ckd in iranian children. materials and methods in a cross-sectional study etiology and outcome of 372 children aged 3 months to 18 years with ckd was studied during the period 199...