Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respe...

the aim of this study was to assess the predictive effect of the ebmt risk score on the outcomes of allogeneic stem cell transplantation in a relatively homogenous group of acute myelogenous leukemia (aml) patients regarding the occurrence of acute and chronic graft versus host disease (gvhd). this historical cohort study included adult patients (≥ 15 years old) with aml (n=363) who received al...

eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (bmt) from hla-matched siblings during the period of 1990 to 1996. the conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. antilymphocyte globulin (alg) and cyclosporine were used for rejection and acute gvhd prophylaxis, respective...

Background: It is suggested that HA-1 mismatching among hematopoietic stem cell transplanted recipients-donors is associated with acute graft-versus-host disease (aGVHD). So the aim of this study was to evaluate HA-1 frequency and examine the correlation between HA-1 disparity and GVHD patients who received transplantation from a HLA-identical sibling. Samples and Methods: the DNA was extracted...

Background: Bone marrow transplantation (BMT) is considered as a curative therapy for a broad range of diseases. However, complications such as relapse and graft versus host disease (GVHD) may be observed following BMT. Chimerism analysis serves as a reliable indicator of transplant outcome. Complete chimerism refers to the complete replacement of hematopoietic system by donor cells, while mixe...

Antigen-stimulated naïve T cells differentiate into effector and memory cells, of which resident (TRM) reside permanently in organ tissues. Involvement TRM has been indicated pathological conditions various skin diseases. CD122, is the β chain subunit interleukin (IL)-2 IL-15 receptors, expressed on immune including cells. To investigate whether CD122 signaling CD8+ mediates development mucocut...

BACKGROUND BAFF (B cell-activating factor) and APRIL (a proliferation-inducing ligand) are members of the tumor necrosis factor family and promote B cell survival and proliferation. We evaluated the correlation between serum concentration of BAFF or APRIL and severity of acute graft-versus-host disease (GVHD). METHODS Fifteen patients who received allogeneic hematopoietic stem transplantation...

Chronic graft-versus-host disease (GVHD) is an important complication of bone marrow transplantation. We analyzed risk factors for chronic GVHD in 2,534 recipients of HLA-identical sibling transplants surviving at least 90 days after transplantation. The actuarial probability of developing chronic GVHD within three years posttransplant was 46% +/- 3% (95% confidence interval). The most importan...

We have analyzed the long term outcome of 197 patients who were treated for grade II to IV acute graft-versus-host disease (GVHD) following histocompatible allogeneic bone marrow transplantation (BMT). Of 469 recipients of sibling donor allografts performed at our center between January, 1979 and October, 1987, 197 patients (42%) developed greater than or equal to grade II acute GVHD at a media...