though intravenous (iv) magnesium sulphate (mgs04) has additive effect to beta-2 agonists, its additive benefit in face of combination therapy with beta-2-agonists and ipratropium (standard therapy of severe acute exacerbation of asthma) remains unaddressed. the aim of this investigation was to evaluate the role of iv mgso4 when used as an adjunct to standard therapy of severe exacerbations of ...

the role of chlamydia pneumoniae in asthma has drawn much attention in recent years. in this study we assessed the prevalence of c. pneumoniae infections in patients with chronic stable and acute exacerbation of asthma and compared it with normal population. twenty adult patients with chronic stable asthma and 21 patients with acute exacerbations of asthma and 41 matched control subjects were s...

increased arginase activity in the airways decreases l-arginine and causes deficiency of bronchodilating and anti-inflammatory nitric oxide (no) in asthma. as, it is suggested that l-arginine may have therapeutic potential in asthma treatment, we aimed to investigate the effects of inhaled l-arginine on oxygen saturation (sao₂) and airway histology in a murine model of acute asthma. twenty eigh...

ykl-40 (chitinase-3-like-1) has been introduced as a marker of inflammation in asthma. the aim of this study was to determine the role of ykl-40 in asthma and to evaluate the relationship between ykl-40 and asthma severity. in the study, 60 non-smoker asthma patients without additional diseases (aged between 20-60 years, female: 34) were grouped [group i: well controlled asthma patients (n: 30)...

  Background and Objectives: Apoptosis of eosinophils is of significant value in assessing the airway inflammation in patients with asthma. Our purpose was to investigate the degree of expression of the Bcl-2 protein in sputum eosinophils during acute asthma exacerbation and its relationship with exacerbation severity.    Materials and Methods: The study was carried out in Mostafa Khomeini Ho...

the purpose of this study was to determine the clinical significance of changes in the plasma  adiponectin  concentration  in  patients  with  bronchial  asthma  and  to  test  the association between the single nucleotide polymorphisms (snps) rs2241766 and rs1501299 in the adipoq gene and bronchial asthma in the chinese li population.we selected 120 cases and 120 controls, and plasma adiponect...

occupational asthma has been reported  to  be the most  common  chronic respiratory occupational disease in many developed countries, and  as with other  occupational lung diseases, occupational asthma is potentially preventable. we report  the case of a 24-year-old baker who experienced pneumomediastinum as a consequence of workplace exposure. this is the first report of pneumomediastinum as a...

magnesium (mg) is the second most abundant intracellular cation and is involved in numerous physiological functions, including protein folding, intracellular signaling and enzyme catalysis. it has been shown that magnesium deficiency exacerbates pulmonary airways hyperreactivity. several studies suggest that magnesium level has no effect on asthma but others had shown a contributory effect. bec...

A 24 years old man with known history of asthma came acute presentation ascending weakness for4 days following flu like symptoms and worsening asthma. His complete blood counts showed elevated eosinophil count. Nerve conduction neuropathy. Diagnosed Churg Strauss syndrome due to presence asthma, eosinophilia, neuropathy pulmonary infiltrates. is systemic eosinophilic vasculitis involving multip...