Sickness behavior appears to be the expression of a central motivational state that reorganizes the organism’s priorities to cope with infectious pathogens.To evaluate the effect of selective and non selective COX inhibitors in lipopolysaccharides induced sickness behaviour,rats were subjected to the forced swim test (FST), open field test,actophotometer. LPS(10mcg/kg i.p). administration incre...

Anxiety is a most common emotional disorder affecting 20% of adult population worldwide. Eclipta alba is having memory enhancing quality & traditionally used for this purpose. Since paucity of data available for this clinical use, the present work was undertaken to study the anti anxiety & sedative effects of Ethanolic extract of leaves of Eclipta alba(EEEA) in albino rats using thiopental sodi...

The present study was undertaken to evaluate the anxiolytic activity of methanolic extract of Sapindus mukorossi Gaertn.(Sapindaceae). The anxiolytic activity was evaluated by Elevated plus maze, Y-maze, Hole-board, Actophotometer, and Marble-burying behavior models. The efficacy of the extract (200 and 400 mg/kg) was compared with the standard anxiolytic drugs Diazepam (2 mg/kg) and Fluoxetine...

BACKGROUND AND OBJECTIVES In patients with epilepsy, a common comorbidity diagnosed is depression. Temporal lobe epilepsy or post status epilepticus (SE) animal model establish and validate the co morbidity and common pathogenesis of depression and epilepsy. Elevation in serotonin concentration gives an inhibitory response to epileptic discharge and stabilizes the depressed mood disorder. Piper...

The objective of the present study was to evaluate the anxiolytic, antidepressant, and anticonvulsant activity of the methanolic extract of Swertia corymbosa (SCMeOH). After acute toxicity test, oral treatment with SCMeOH at doses of 125, 250, and 500 mg/kg behavioral models of open field, elevated-plus-maze, actophotometer, rotarod, pentylenetetrazole, isoniazid, and maximal electroshock induc...

Herbal medicines are gaining growing interest because of their costeffective, ecofriendly attributes and true relief from disease condition. Sarcostemma acidum was documented in many folklore practices for various psychiatric conditions. It has been dealt with in detail in “SHRUSHRUTHA SAMHITHA”. Ethyl Acetate Extract of the whole plant Sarcostemma acidum (EASA) was evaluated for psychopharmaco...

Anxiety related disorders are the most common mental illnesses and major cause of disability in man. Anxiolytic activity of methanol extract of leaves of A. brasiliana (L.) Kuntze (MEAB) was evaluated using hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration test (LDE) in mice. Its locomotor activity was studied using actophotometer and anticonvulsant effect wa...

The swimming endurance test, anoxic tolerance and basal activity by actophotometer were used to assess the antistress of a seven-day therapy (200 400 mg/kg, p.o.) ethanolic extract Coriandrum sativum (EECS) aerial parts. A method for measuring in vitro antioxidant hydroxyl radicals was used. In all examined models, at both doses demonstrated effects. duration stay on rotarod, EECS treated rats ...

Methanolic and ethyl acetate extract of A. galanga showed significant central nervous system (CNS) stimulant activity in mice using actophotometer and rotarod test. CNS stimulation at a dose of 500 mg/kg was comparable with standard drugs caffeine and amphetamine derivative modalart. The extracts did not shown any depressant effect in forced swim or tail suspension tests. It can be concluded th...

The objective of the present study was to formulate and evaluate a thermoreversible formulation containing rizatriptan benzoate for intranasal administration. Chitosan and aqueous β−glycerolphosphate were mixed in cold condition to obtain chitosan-β−glycerolphosphate mixtures, which served as the thermoreversible systems. Rizatriptan benzoate was incorporated at a fi nal strength of 25 mg/ml. B...