نتایج جستجو برای: activation gene 3 lag
تعداد نتایج: 3021237 فیلتر نتایج به سال:
مقدمه: سلول های t تنظیمی cd4 + foxp3 + دارای نقش عمده در تعدیل پاسخ های ایمنی و به علاوه، ایجاد تحمل ایمنی در جلوگیری از بروز بیماری های خود ایمن می باشند. همچون بسیاری از بیماری های خود ایمن دیگر، پیشنهاد می شود که مولتیپل اسکلروزیس (ms یا multiple sclerosis) نیز به عنوان یک بیماری سیستم عصبی مرکزی، با نقص عملکردی یا تعدادی از این قبیل سلول ها همراه باشد. ژن 3 فعال سازی لنفوسیت (lag-3 یا lymph...
A number of cell surface structures are thought to belong to the Ig superfamily (IgSF) t because they contain at least one domain with a characteristic folding pattern, called the Ig fold (reviewed in reference 1) . Several of these molecules have critical functions in immune responses . In addition to ensuring specific antigen recognition (Ig, TCR), they may function as monomorphic ligands cri...
LAG‐3 (Lymphocyte Activation Gene‐3) Negatively Regulates Environmentally‐Induced Autoimmune Disease
Central ossifying fibroma is a benign, slow-growing tumor of mesenchymal origin with a predilection for the mandibular premolar and molar areas. The immunophenotype of T cells involved in the antitumor response against this benign tumor is unknown. In this case report, we described a case of a 48-year-old woman presenting with a very large recurrent ossifying fibroma in the mandible, which was ...
The lymphocyte activation gene-3 (LAG-3) molecule is a T cell activation Ag closely related to CD4 at the gene and protein levels. We investigated whether LAG-3 itself may down-regulate the immune response by interfering with TCR signaling. The binding of Ab to the LAG-3 molecule followed by cross-linking (XL) inhibits cell proliferation and cytokine secretion in response to CD3XL on activated ...
Stimulatory and inhibitory co-receptors play fundamental roles in the regulation of the immune system. We describe a new mouse model of spontaneous autoimmune disease. Activation-induced cytidine deaminase-linked autoimmunity (aida) mice harbor a loss-of-function mutation in the gene encoding lymphocyte activation gene 3 (LAG-3), an inhibitory co-receptor. Although LAG-3 deficiency alone did no...
Preventing activation of diabetogenic T cells is critical for delaying type 1 diabetes onset. The inhibitory molecule lymphocyte activation gene 3 (LAG-3) and metalloprotease tumor necrosis factor-α converting enzyme (TACE) work together to regulate TH1 responses. The aim of this study was to determine if regulating redox using a catalytic antioxidant (CA) could modulate TACE-mediated LAG-3 she...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید