conclusions according to the results, ud is able to decrease glucose level and improve insulin release in t2dm. in addition, as ud is able to induce a small increase in ampk activity, it is possible that the anti-hyperglycemic effect of ud is mediated by insulin secretion and the possible changes in ampk levels. results fbg levels of the drug group were significantly decreased compared with the...

When an experience is encrypted into a long-lasting memory, it is believed that specific sets of neurons in the brain of the animal undergo changes including the strengthening of preexisting synapses and the growth and maintenance of new synaptic connections. These activity-dependent synaptic changes appear to require the coordination of a variety of cellular processes in spatially separated ce...

diabetic retinopathy is the lead among causes of blindness in north america. glucose-induced endothelial injury is the most important cause of diabetic retinopathy and other vascular complications. extracellular signal-regulated kinase 5 (erk5), also known as big mitogen-activated protein kinase 1 (bmk1), is a member of mitogen-activated protein kinases (mapk) family. physiologically, it is cri...

The growth and differentiation of normal cells are controlled by protein-tyrosine kinases, which serve as receptors for a wide variety external signals. Small protein modules called Src homology 2 (SH2) SH3 domains mediate protein-protein interactions in signaling pathways that triggered tyrosine kinases. SH2 domain, module around 100 amino acids, is present kinase targets within the cell. recr...

introduction: increased oxidative stress is widely accepted to be a factor in the development and progression of alzheimer’s disease. triazine derivatives possess a wide range of pharmacological activities including anti-oxidative and anti-in.ammatory actions. in this study, we aimed to investigate the possible protective effect of 3-thioethyl-5,6-dimethoxyphenyl-1,2,4-triazine (tedmt) on h2o2-...