Technical details influence the diagnostic accuracy of the 1 mg ACTH stimulation test Matthew Wade, Smita Baid, Karim Calis, Hershel Raff, Ninet Sinaii and Lynnette Nieman Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development and Pharmacy Department, National Institutes of Health, Clinical Center, Building 10, CRC, 1 East, Room 1-3140, 10 Cent...

BACKGROUND Several studies in the last few years have shown that the standard 250 micro g dose used in ACTH stimulation test may be very high and have suggested that a dose of 1 micro g may be sufficient for evaluating hypothalamo-pituitary adrenal (HPA) axis. AIMS To evaluate the role of low dose ACTH stimulation test in patients with suspected Secondary Adrenal Insufficiency (SAI). SUBJEC...

     The goal of this study was to evaluate the effects of quercetin and ACTH injection on prevention of development of morphine tolerance and dependence in mice. In this study different groups of mice received morphine (40 mg/kg, i.p.) plus quercetin (5, 10, 25 mg/kg, ip), ACTH (1, 2.5, 5 IU/mice, i.p.), or combination of quercetin (5 mg/kg) and ACTH (1 IU/mice) once a day for four days. Toler...

OBJECTIVES Adrenal insufficiency is often diagnosed by short synacthen test using intravenous Injection Synacthene, which is not marketed in India officially. To overcome this problem this study was planned to validate and use Acton Prolongatum (Ferring pharmaceuticals) as intramuscular ACTH stimulation test for evaluation of adrenal function. METHODS This study was planned in two groups. Fir...

INTRODUCTION A standard short Synacthen test (SST) is the conventional diagnostic test for primary hypoadrenalism. Measuring simultaneous plasma cortisol and adrenocorticotrophin hormone (ACTH) and using the cortisol: ACTH ratio as a first-line test may be safer and more convenient than performing a SST. METHODS A retrospective study of 349 patients who had a SST with simultaneous baseline pl...

OBJECTIVE Treatment of intractable seizures other than spasms is difficult and controversial. There are few studies on efficacy of adrenocorticotropic hormone (ACTH) in treatment of patients with intractable seizure. MATERIALS & METHODS Twenty-five patients with intractable seizure other than spasm including 14 boys and 11 girls with median age of 58 months referred to university clinics of P...

OBJECTIVE Corticotropin releasing hormone (CRH) test does not reliably distinguish Cushing's disease (CD) from normality or pseudo-Cushing state (PC). We assessed whether this could be achieved with a novel approach while preserving the ability of the test to distinguish CD from ectopic ACTH syndrome (EAS). Design Retrospective/prospective study. SUBJECTS AND METHODS We studied 51 subjects wi...