OBJECTIVE The estimated prevalence of acromegaly is 40-125 per million. The diagnosis of acromegaly is often delayed due to deficits in recognizing the signs of the disease. It is not known how many subjects with increased IGF-1 levels have acromegaly. We aimed to assess the prevalence of acromegaly in primary care by screening for elevated IGF-1 levels. DESIGN A cross-sectional, epidemiologi...

Early carbohydrate metabolism disorders (ECMDs) and diabetes mellitus (DM) are frequently associated with acromegaly. We aimed to assess the prevalence of ECMDs in patients with acromegaly and to compare the results with those in adults without acromegaly using two population-based epidemiologic surveys. We evaluated 97 patients with acromegaly in several phases of their disease (mean age, 56 y...

Acromegaly is a neuroendocrine disease with diverse clinical manifestations that develop over long period. In the process of examining patient, it may be necessary to conduct differential diagnosis acromegaly various syndromes and conditions, including such rare as pachydermoperiostosis. Features presentation are given in description case from our practice.

BACKGROUND Acromegaly is a chronic disorder characterized by excess growth hormone secretion and elevated insulin-like growth factor-1 levels most often caused by a pituitary adenoma. Clinical presentation of the disease includes coarsening of the facial features, soft-tissue swelling of the hands and feet, and overgrowth of the frontal skull and protrusion of the jaw, as well as joint symptoms...

BACKGROUND In acromegaly, the gastrointestinal system is under the influence of excessive growth hormone (GH) and insulin like growth factor-1 (IGF-I). Increased bowel length and delayed transit time may cause functional disturbance of the bowel. The objective of the current study is to evaluate the frequency of irritable bowel syndrome (IBS) in cases with acromegaly. PATIENTS AND METHODS Twe...

Acromegaly is a rare disease with nonspecific symptoms with acral enlargement being almost universally present at diagnosis. The estimated prevalence is 40-125 cases/million but targeted universal screening studies have found a higher prevalence (about 10 fold). The aim of the ACROSAHS study was to investigate the prevalence of acromegaly and acromegaly comorbidities in patients with sleep apne...

conclusions the primary treatment for gh-producing adenoma is surgery; however, this patient has high surgical risk from her severe cardiomyopathy. radiotherapy poses a greater risk because of increased cerebrovascular mortality. somatostatin receptor ligands are significantly associated with improvement of cardiovascular and hemodynamic parameters. dopamine agonists must be considered regardle...

BACKGROUND Acromegaly is an uncommon endocrine disorder. Pregnancy is an unusual event in acromegalic females because fertility is often reduced. With the advent of advanced surgical and medical management, more acromegalic women will achieve pregnancy. Reports of pregnancy in acromegaly and recurrent acromegaly postpartum are rare. OBJECTIVE To present a rare occurrence of pregnancy in acrom...

Abstract Acromegaly is associated with cardiovascular disease, the principal cause of increased mortality. Direct cardiac effects GH/IGF-1 are cardiomyocyte growth and contractility, remoddeling. Other important risk factors in acromegaly hypertension, valvular diseases, arrhytmias. Older patients long-term uncontrolled disease may develop congestive heart failure as end-stage acromegalic cardi...