Erythema Multiforme (EM) is an acute, immune–mediated condition characterized by the appearance of distinctive target like lesions on the skin. It is characterized by acrally distributed, distinct target like lesions with concentric color variation, sometimes accompanied by oral, genital, or ocular mucosal erosions or a combination of these [1]. Although EM is usually self-limiting, frequent ep...

dear editor-in-chief   lesional histopathological features in pityriasis rosea (pr) are non-specific (1).  our aim here is to investigate whether a histopathological take-off sign (tos) is associated with pr.

OBJECTIVES Erythema multiforme (EM) is characterized by symmetrical acrally distributed target lesions; however, other conditions can mimic the clinical features of EM. Although it is typically self-limiting, alternative diagnoses may be life-threatening and require immediate identification and treatment. This study aimed to investigate the clinical spectrum and accuracy of diagnosis of pediatr...

THE CLASSIFICATION of seleroderma has been a controversial subject primarily because adequate follow-up studies have been lacking. It is generally agreed that localized forms of seleroderma such as morphea and linear seleroderma are not progressive or systemic diseases and have a good prognosis. The same is true for seleroderma confined to the fingers and toes of patients with long-standing Ray...

Cutaneous manifestation of COVID 19 in children has not yet been reviewed systematically. Hence, this review gives the clinicians a future direction to be vigilant for skin presentations during pandemics. The Pubmed database used literature search with keywords 19, children, and different combinations. Articles published English cases age one month 18 years were eligible. outcome included varie...

INTRODUCTION Chilblains or perniosis is an acrally located cutaneous eruption that occurs with exposure to cold. Chilblains can be classified into primary and secondary forms. The primary or idiopathic form is not associated with an underlying disease and is clinically indistinguishable from the secondary form. The secondary form is associated with an underlying condition such as connective tis...

Dear Editor-in-Chief   Lesional histopathological features in pityriasis rosea (PR) are non-specific (1).  Our aim here is to investigate whether a histopathological take-off sign (TOS) is associated with PR.

Jean-Claude Roujeau, MD, Service de Dermatologie, Hôpital Henri-Mondor, F–94010 Créteil (France) One hundred and thirty years after the original description of von Hebra, erythema multiforme (EM) is still giving rise to many controversies on all the aspects which constitute a disease as an entity. Clinical definition and nosology, pathology, etiology, physiopathology and treatment remain the su...