this is the first description of the polymorphisms of arylalkylamine-n-acetyltransferase (aa-nat) gene in indian goats with different reproductive traits (twinning percentage and age of sexual maturity). based on the important role of aa-nat in reproduction, it is considered as a possible candidate gene for this trait. two novel synonymous snps, c825t (exon2) and c1249t (exon3) were identified....

abstract benzylisoquinoline alkaloids are a diverse group of nitrogenous compounds which is found in about 20% of plant species. isolation of effective genes involved in morphine biosynthesis of opium poppy is very important in the production of specific which can be achieved using metabolic engineering techniques. in this biosynthesis pathway, the key enzyme sat is involved in the conversion o...

Heparin acetyl-CoA:alpha-glucosaminide N-acetyltransferase (N-acetyltransferase, EC 2.3.1.78) is an integral lysosomal membrane protein containing 11 transmembrane domains, encoded by the HGSNAT gene. Deficiencies of N-acetyltransferase lead to mucopolysaccharidosis IIIC. We demonstrate that contrary to a previous report, the N-acetyltransferase signal peptide is co-translationally cleaved and ...

Polarization of the actin cytoskeleton is vital for collective migration cells in vivo. During invasive border cell Drosophila, polarization directly controlled by Hippo signaling complex, which resides at contacts between cluster. Here, we identify, a genetic screen deubiquitinating enzymes involved migration, an essential role nonstop/USP22 expression pathway components expanded and merlin. L...

The effects of semi-chronic stress on neuronal morphology and choline acetyltransferase were studied by injecting rats with dexamethasone. It was found that in the dexamethasone-treated rats the choline acetyltransferase activity had increased in the area where the fibers from the perforant pathway synapse with the granular cell layer of the dentate gyrus and also where the mossy fibers of the ...

Acetyl-CoA:N-hydroxyarylamine O-acetyltransferase is an enzyme involved in the metabolic activation of N-hydroxyarylamines derived from mutagenic and carcinogenic aromatic amines and nitroarenes. The O-acetyltransferase gene of Salmonella typhimurium has been cloned, and new Ames tester substrains highly sensitive to mutagenic aromatic amines and nitroarenes have been established in our laborat...