Silica Vanadic Acid, SVA, (oxo-vanadium has been supported on silica) as a dual Lewis and Bronsted acid ability was prepared and efficiently catalyzed one-pot multi-component condensation of enolizable ketones or alkyl acetoacetates with aromatic aldehydes, acetonitrile and acetyl chloride. The described reaction was produced β-acetamido ketone or ester derivatives in high to excellent yields i...

Silica Vanadic Acid, SVA, (oxo-vanadium has been supported on silica) as a dual Lewis and Bronsted acid ability was prepared and efficiently catalyzed one-pot multi-component condensation of enolizable ketones or alkyl acetoacetates with aromatic aldehydes, acetonitrile and acetyl chloride. The described reaction was produced β-acetamido ketone or ester derivatives in high to excellent yields i...

β -Acetamido ketones are valuable building blocks for the preparation of β -amino ketones or β -amino alcohols such as the antibiotic nikkomycins [1] and neopolyoxines [2]. α-Acetamido ketones are obtained in the Dakin-West reaction [3] and β -acetamido ketones by the Iqbal route. In the latter, an aromatic aldehyde, an enolizable ketone and acetonitrile are condensed in the presence of acetyl ...

Treatment of 1-(n-butyl)-3-N-(2-Ar)acetamido-1, 3-imidazolium chloride (Ar=furylmethyl,phenylmethyl) with excess K2CO3 and [PdCl2(L−L)] (L−L=2 PPh3, dppf) afforded orange compounds composition [(1-(n-butyl)-3-N-(2-Ar)acetamido-1,3-imidazol-2-ylidene)]2Pd (Ar=furylmethyl; phenylmethyl). These complexes were characterized by NMR (1H 13C{1H} NMR), IR micro-analysis data. Subsequently, the catalyti...

Iodinated X-ray contrast agents are considered to be nondegradable by microorganisms. The decomposition of the ionic X-ray contrast agents Diatrizoate (3,5-di(acetamido)-2,4,6-triiodobenzoic acid) and Iodipamide (3,3'-adipoyl-diimino-di(2,4,6-triiodobenzoic acid) and related triiodinated benzoates (Acetrizoate [3-acetylamino-2,4, 6-triiodobenzoic acid] and Aminotrizoate [3-amino-2,4, 6-triiodob...

1. The isolation, characterization and properties of two by-products in the preparation of 2-acetamido-3,4,6-tri-O- acetyl-2-deoxy-beta-d-glucopyranosylamine are described. They are bis(2-acetamido-2-deoxy-d-glucopyranosyl)amines. 2. An independent synthesis of the bis-glycopyranosylamines is reported and conditions are given for their preparation in high yield. 3. Further improvements are give...

A novel synthesis of furanodictines A [2-acetamido-3,6-anhydro-2-deoxy-5-O-isovaleryl-D-glucofuranose (1)] and B [2-acetamido-3,6-anhydro-2-deoxy-5-O-isovaleryl-D-mannofuranose (2)] is described starting from 2-acetamido-2-deoxy-D-glucose (GlcNAc). The synthetic protocol is based on deriving the epimeric bicyclic 3,6-anhydro sugars [2-acetamido-3,6-anhydro-2-deoxy-D-glucofuranose (4) and 2-acet...

The series: 9-methyl, 9-isopropyl, 9-cyclohexyl, 9,9-dimethyl, 9,9-diethyl, and the unsubstituted parent 2,7-bis (acetamido) fluorene were synthesized from the corresponding 9-substituted fluorenes. The two routes employed consisted of either (1) dinitration, reduction to the diamine, and diacetylation, or (2) Friedel-Crafts diacylation, then rearrangement via the Schmidt reaction. This provide...

The series: 9-methyl, 9-isopropyl, 9-cyclohexyl, 9,9-dimethyl, 9,9-diethyl, and the unsubstituted parent 2,7-bis (acetamido) fluorene were synthesized from the corresponding 9-substituted fluorenes. The two routes employed consisted of either (1) dinitration, reduction to the diamine, and diacetylation, or (2) Friedel-Crafts diacylation, then rearrangement via the Schmidt reaction. This provide...