The effects of acepromazine on human ether-à-go-go-related gene (hERG) potassium channels were investigated using whole-cell voltage-clamp technique in human embryonic kidney (HEK293) cells transfected with hERG. The hERG currents were recorded with or without acepromazine, and the steady-state and peak tail currents were analyzed for the evaluating the drug effects. Acepromazine inhibited the ...

UNLABELLED The sedative, propofol-sparing and cardiopulmonary effects of acepromazine, midazolam, butorphanol and combinations of butorphanol with acepromazine or midazolam in goats were evaluated. Six healthy Boer - Indigenous African crossbreed goats were by randomised cross-over designated to 6 groups: Group SAL that received saline, Group ACE that received acepromazine, Group MID that recei...

OBJECTIVE To evaluate the effect of acepromazine or xylazine on Schirmer tear test 1 results in clinically normal cats. ANIMALS Sixteen healthy cross-breed cats. PROCEDURE The animals were randomly divided into two groups of eight cats each. The first group was sedated with acepromazine alone (0.2 mg/kg) and the second group received only xylazine (2 mg/kg). All cats had Schirmer tear test ...

Adequate sedation and excellent depth of analgesia were recorded in all the four groups after induction to end surgical procedure, however, significantly higher score observed group D lower was A comparison other groups. Butorphanol with acepromazine, midazolam, or dexmedetomidine provides adequate dogs, before propofol, so it made handling animals proper safe induction. Dexmedetomidine produce...

Objective: To determine the effect of intravenous acepromazine on the electroencephalogram (EEG) of normal Beagle dogs. Sample Population: Twelve healthy beagle dogs Procedures: Dogs were sedated and the EEG recorded for 20 minutes. Acepromazine was then injected intravenously in either low or high dose with the order chosen randomly and EEG recording continued for 30 minutes. Each dog received...

The aim of the present study was to compare the effect of (detomidine 150 mg/kg) mixed (Ketamine 35mg/kg) in one syringe with (Acepromazine 2mg. /Kg B. W.) mixed (Ketamine 35mg/kg) in one syringe. First protocol uses detomidine and Ketamine in one syringe administered intramuscularly and the second protocol uses acepromazine and ketamine in one syringe administered intramuscularly. Data were co...

1.25 g acepromazine maleate was consumed by a young woman in an unsuccessful suicide attempt. The drug is used extensively as an anesthetic premedication in veterinary practice. The woman had worked as a lay veterinary assistant. The clinical signs of toxicity were in part consistent with phenothiazine over-dosage in the human and were inconsistent with signs usually observed in animals.

OBJECTIVES The aim of the present study was to quantify by accelerometry the trotting pattern of adult horses sedated with two different doses of acepromazine, in order to assess the use of this drug in equine lameness evaluations. METHODS Seven mature horses were used and three treatments were administered to each horse: saline solution, acepromazine (0.01 mg/kg), and acepromazine (0.02 mg/k...

BACKGROUND Dog breeds with the ABCB1-1Δ mutation have substantially truncated nonfunctional P-glycoprotein. Dogs homozygous for this mutation (mut/mut) are susceptible to the toxic adverse effects of ivermectin, loperamide, and vincristine. Anecdotal reports suggested ABCB1 mut/mut dogs showed increased depth and duration of acepromazine sedation. HYPOTHESIS/OBJECTIVES That ABCB1 mut/mut dogs...

BACKGROUND Aim of the study was to compare the effect of neuroleptic sedation with acepromazine and neuroleptanalgesia with acepromazine and buprenorphine on thermal thresholds (TT) obtained at the nostrils and at the withers. The study was carried out as a randomized, blinded, controlled trial with cross-over design. Thermal thresholds were determined by incremental contact heat applied to the...