background: most of our current understanding of the biological effects of exposure to ionising radiation is based on conventional cytogenetic techniques, which enable us to determine the relationship between chromosomal aberration and dose received by radiation workers. however, conventional techniques have numerous limitations and chromosomal aberrations can be easily missed. since fish plays...

Although rare, accidental irradiation overexposures remain difficult to treat, mainly because of a complex physiopathology, known as the acute radiation syndrome (ARS). As a consequence, the issue remains fatal for most of high dose radiation accident victims. This is due in part through the lack of biological indicators able to give information about the extent of radiation-induced damage. Suc...

background: after radiation therapy (rt), some health hazards including dna damages may occur where melatonin can play a protective role due to free radical generation. on the other hand, serious accidental overexposures may occur during rt due to nuclear accidents which necessitate the need for study on exposure to high-dose radiations during treatments. objective: the aim of this study was to...

Background: After radiation therapy (RT), some health hazards including DNA damages may occur where melatonin can play a protective role due to free radical generation. On the other hand, serious accidental overexposures may occur during RT due to nuclear accidents which necessitate the need for study on exposure to high-dose radiations during treatments.Objective: The aim of this study was to ...

Possibility of protection from ionizing radiation when an organism, as a unit, absorbs radiated energy practically does not exist. In the previous investigations no medicine has been invented that could successfully be applied in therapy of radiation diseases. Today, in the cases of accidental irradiation with high doses of ion radiation and developing of radiation syndrome, today it is possibl...

Our long-term goal is to use angiotensin converting enzyme (ACE) inhibitors to mitigate the increase in lung collagen synthesis that is induced by irradiation to the lung, which could result from accidental exposure or radiological terrorism. Rats (WAG/RijCmcr) were given a single dose of 13 Gy (dose rate of 1.43 Gy/min) of X-irradiation to the thorax. Three structurally-different ACE inhibitor...

Lung injury is one of the major concerns for chest cancer patients that undergo radiotherapy as well as persons exposed to an accidental radiological event. Reduction/oxidation (redox) system plays a key role in lung injury via chronic upregulation of pro-oxidant enzymes. NOX2 and NOX4 are two important reactive oxygen species generating enzymes that are involved in radiation toxicity in some o...

Hippophae rhamnoides has diverse therapeutic applications in Indian, Chinese and Tibetan medicine. Irradiation (accidental/ therapeutic) causes immunosuppression and inflammation. This study investigated effects of our preparation from leaves of H. rhamnoides (code SBL-1), on modification of immunosuppression and inflammation in whole body irradiated (10 Gy) mice. One time treatment with SBL-1 ...

Abstract Background Cranial radiation therapy for treating childhood malignancies in the central nervous system or accidental exposure may result neurological side effects surviving adults. As tissue homeostasis is maintained by stem cells, understanding effect of on neural cells will provide clues managing effects. Drosophila embryos were used as a model whose sensitivity to irradiation-induce...