نتایج جستجو برای: acanthosis nigricans

تعداد نتایج: 1486  

Journal: :Archives of dermatology 2007
David R Berk Elaine B Spector Susan J Bayliss

BACKGROUND Acanthosis nigricans is a feature of several syndromes caused by activating mutations of the fibroblast growth factor receptor 3 gene (FGFR3), including Crouzon syndrome with acanthosis nigricans, thanatophoric dysplasia, and severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN syndrome). OBSERVATIONS We describe a healthy 4-year-old African American girl...

Journal: :The Turkish journal of pediatrics 2005
Selim Kurtoğlu M Emre Atabek Mehmet Keskin Ozlem Canöz

A case is described of a three-day-old female with salt wasting type of 21-hydroxylase deficient congenital adrenal hyperplasia who presented with acanthosis nigricans of both axillae. Following corticosteroid and mineralocorticoid therapy for disease, the acanthosis nigricans resolved. It is believed that this is the first reported case of acanthosis nigricans occurring in association with con...

2014
Manal Mustafa Nabil Moghrabi Bassam Bin-Abbas

FGFR3 mutations cause wide spectrum of disorders ranging from skeletal dysplasias (hypochondroplasia, achondroplasia, and thanatophoric dysplasia), benign skin tumors (epidermal nevi, seborrhaeic keratosis, and acanthosis nigricans), and epithelial malignancies (multiple myeloma and prostate and bladder carcinoma). Hypochondroplasia is the most common type of short-limb dwarfism in children res...

2014

Objectives: Acanthosis nigricans refers to the velvety, black hyperpigmentation seen in the flexures. It is a cutaneous marker for insulin resistance (IR), some metabolic disorders and rarely malignancy. When secondary to IR, it is asymptomatic, except for the hyperpigmentation. The neck is the most accessible and easiest to grade. Our aim was to identify the predictive value of the grades of a...

Journal: :JAMA dermatology 2013
Adnan Mir Timothy Wu Seth J Orlow

IMPORTANCE Crouzon syndrome with acanthosis nigricans is a distinct disorder caused by a mutation in the FGFR3 gene, featuring craniosynostosis, characteristic facial features, and atypical and extensive acanthosis nigricans. Other cutaneous findings have not been thoroughly described. OBSERVATIONS We report 6 cases and summarize the existing literature with regard to the cutaneous manifestat...

2011
Sang-Sin Lee Nam-Ji Jung Myung Im Young Lee Young-Joon Seo Jeung-Hoon Lee

Acanthosis nigricans is a symmetric eruption characterized by the presence of a hyperpigmented, velvety cutaneous thickening, that can develop on any part of the body, but characteristically affects the flexural areas of the body. The velvety hyperkeratotic lesions can be located on the dorsum of the hands and feet in dark-skinned people in the form of a variant of acanthosis nigricans called a...

Atyeh Ebadi Behrooz Barikbin Zahra Saffarian

Crouzon syndrome is a rare inherited autosomal dominant syndrome characterized by craniosynostosis, midface hypoplasia. Acanthosis nigricans may be associated with Crouzon syndrome, but it differs from the classic crouzon syndrome. This is a report of a 30-year-old-woman who presented acanthosis nigricans coexist with crouzon syndrome.

Journal: :Hong Kong medical journal = Xianggang yi xue za zhi 2014
H Y Ng Jack H M Young K F Huen Louis T W Chan

OBJECTIVES. To investigate the demographic characteristics and insulin resistance in local overweight/obese Chinese children with and without acanthosis nigricans, and the associations of acanthosis nigricans with insulin resistance and other cardiometabolic co-morbidities. DESIGN. Case series with cross-sectional analyses. SETTING. A regional hospital in Hong Kong. PATIENTS. Chinese children a...

2014
Marta Stawczyk-Macieja Aneta Szczerkowska-Dobosz Roman Nowicki Hanna Majewska Michał Dubowik Małgorzata Sokołowska-Wojdyło

Malignant acanthosis nigricans is a rare paraneoplastic skin syndrome mostly associated with gastric adenocarcinoma. Florid cutaneous papillomatosis and tripe palms syndrome are considered to be abortive clinical variants of acanthosis nigricans. Clinical manifestations include pruritic, hyperkeratotic and hyperpigmented plaques with a subsequent formation of velvety papillomas in the involved ...

Journal: :Anais brasileiros de dermatologia 2012
Caroline Evelin Nascimento Kluczynik Larissa Soares Mariz Larissa Camila Ferreira Souza Gabriela Beserra Solano Fernanda Cruz de Lira Albuquerque Carla Campos Muniz Medeiros

BACKGROUND Studies have suggested an association between the presence of acanthosis nigricans (AN) and the development of diabetes. OBJECTIVE To investigate the association between AN and insulin resistance (IR) in overweight children and adolescents receiving care at the Center for Childhood Obesity, Campina Grande, PB. METHODS This cross-sectional study was conducted between April 2009 an...

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