Insulin-like growth factor binding protein-5 (IGFBP-5) mediates mesangial cell migration through activation of cdc42, and laminin421 binding to alpha(6)beta(1)-integrin (Berfield AK, Hansen KM, Abrass CK. Am J Physiol Cell Physiol 291: C589-C599, 2006). Because glomerular expression of laminin beta(2) is reduced in diabetic rats (Abrass CK, Spicer D, Berfield AK, St. John PL, Abrahamson DR. Am ...

rain is one of the manifestations of the divine blessing for servants which plays a very important role in the life of this human being. man has paid special attention to rain since he stepped on earth. many poets have described rain, used it in their similes and composed poetry out of it. they have used rain as a symbol together with other symbols such as woman, praise, battleground and so man...

We have further explored the immunocytochemical staining method to discriminate renal and nonrenal hematuria, reported by Abrass and Laird (Am J Kidney Dis 1987;9: 44-50). After fixation on slides with acetone, erythrocytes in urine were stained with antiserum against human Tamm-Horsfall protein. Reactions were made visible by using either a fluorescent second antibody or a biotinylated second ...

Rat glomerular mesangial cells (MC) become lipid-laden foam cells when they are exposed to IGF-1. IGF-1 increased accumulation of triglyceride (TG) 2.5-fold in MC after 7 days. TG accumulation resulted from enhanced macropinocytosis and decreased efflux secondary to a 40-50% reduction in peroxisome proliferator-activated receptor (PPAR)-delta (PPARdelta). There was no evidence of primary or sec...

Cardiovascular diseases are the leading cause of mortality and morbidity in developed countries and they are emerging as prominent public health problem in developing countries [1]. In this World Health Organization [1] report, it was stated that 80% of deaths from cardiovascular diseases and 87% of related disability currently occur in low and middle income countries. It was revealed in a stud...

MOTIVATION Searching DNA sequences against a DNA database is an essential element of sequence analysis. However, few systematic studies have been carried out to determine when a match between two DNA sequences has biological significance and this is limiting the use that can be made of DNA searching algorithms. RESULTS A test set of DNA sequences has been constructed consisting of artificiall...

Insulin-like growth factor-binding protein-5 (IGFBP-5) and insulin-like growth factor-I (IGF-I) are produced by human intestinal smooth muscle cells. Endogenous IGF-I stimulates growth and increases IGFBP-5 secretion. IGFBP-5 augments the effects of IGF-I by facilitating interaction of IGF-I with the IGF-I receptor tyrosine kinase. Andress (Andress, D. L. (1998) Am. J. Physiol. 274, E744-E750) ...

THANK you very much for this great honor. I am really pleased to have been selected by my colleagues for this award and to join a long list of past Freeman awardees, many of whom were my own wonderful mentors and senior faculty members, such as David Solomon and John Beck, as well as noted friends and colleagues, including Frank Williams, Bob Butler, Jack Rowe, Chris Cassel, Knight Steel, Evan ...