purpose : to report a case of congenital macular macrovessels case report : an 8-year-old girl was referred for decreased vision in her right eye. her best corrected visual acuity (bcva) in the right eye was 20/200 and in the left eye 20/20. anterior segment examinations were normal in both eyes. posterior segment examination of the right eye showed abnormal macrovessels crossing the macula and...

is the winner of the second prize in the recent Olympus–Current Biology photomicrography competition. The retina has been flat-mounted and stained by indirect immunofluorescence to reveal astrocytes (green) and blood vessels (orange/yellow) that are tightly associated with each other, forming a fine network over the retinal surface. Astrocytes (a type of glial cell) are critical for the develop...

To examine the retinal vascular findings on widefield fluorescein angiography (FA) in fellow eyes of patients with unilateral persistent fetal vasculature (PFV). Retrospective case series. Consecutive PFV evaluated by a single physician at an academic medical center from February 1, 2011, to November 30, 2018. Clinical and demographic information, including age, gender, race, ethnicity, affecte...

distribution of retinal blood vessels (rbvs) in retinal images has an important role in the prevention, diagnosis, monitoring and treatment of diseases, such as diabetes, high blood pressure, or heart disease. therefore, detection of the exact location of rbvs is very important for ophthalmologists. one of the frequently used techniques for extraction of these vessels is region growing-based se...

detecting blood vessels is an important task in retinal image analysis.  the task is more challenging with the presence of bright and dark lesions in retinal images. here, a method is proposed to detect vessels in both normal and abnormal retinal fundus images based on their linear features. first, the negative impact of bright lesions is reduced by using k-means segmentation in a perceptive sp...

PURPOSE Aberrant growth of blood vessels in the eye is a major cause of vision loss, occurring as a complication of diabetic retinopathy, age-related macular degeneration, and retinal vascular occlusions, among others. Whereas in humans, in vivo angiography is routinely used to image such diseases, many animal models of ocular vascular disease and development rely on dissected tissues that may ...

Development of the retinal vascular network is strictly confined within the neuronal retina, allowing the intraocular media to be optically transparent. However, in retinal ischemia, pro-angiogenic factors (including vascular endothelial growth factor-A, VEGF-A) induce aberrant guidance of retinal vessels into the vitreous. Here, we show that the soluble heparan sulfate level in murine intraocu...