نتایج جستجو برای: abcg8

تعداد نتایج: 259  

Journal: :BMC Medicine 2004
Eric L Klett Kangmo Lu Astrid Kosters Edwin Vink Mi-Hye Lee Michael Altenburg Sarah Shefer Ashok K Batta Hongwei Yu Jianliang Chen Richard Klein Norbert Looije Ronald Oude-Elferink Albert K Groen Nobuyo Maeda Gerald Salen Shailendra B Patel

BACKGROUND Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol trafficking characterized by increased plasma plant sterol levels. Based upon the genetics of sitosterolemia, ABCG5/sterolin-1 and ABCG8/sterolin-2 are h...

Journal: :The Journal of clinical investigation 2002
Gregory A Graf Wei-Ping Li Robert D Gerard Ingrid Gelissen Ann White Jonathan C Cohen Helen H Hobbs

Mutations in either ATP-binding cassette (ABC) G5 or ABCG8 cause sitosterolemia, an autosomal recessive disorder of sterol trafficking. To determine the site of action of ABCG5 and ABCG8, we expressed recombinant, epitope-tagged mouse ABCG5 and ABCG8 in cultured cells. Both ABCG5 and ABCG8 underwent N-linked glycosylation. When either protein was expressed individually in cells, the N-linked su...

Journal: :BMC Gastroenterology 2004
Eric L Klett Mi-Hye Lee David B Adams Kenneth D Chavin Shailendra B Patel

BACKGROUND The molecular mechanisms that regulate the entry of dietary sterols into the body and their removal via hepatobiliary secretion are now beginning to be defined. These processes are specifically disrupted in the rare autosomal recessive disease, Sitosterolemia (MIM 210250). Mutations in either, but not both, of two genes ABCG5 or ABCG8, comprising the STSL locus, are now known to caus...

Journal: :Journal of lipid research 2006
Astrid Kosters Cindy Kunne Norbert Looije Shailendra B Patel Ronald P J Oude Elferink Albert K Groen

The main player in biliary cholesterol secretion is the heterodimeric transporter complex, ABCG5/ABCG8, the function of which is necessary for the majority of sterols secreted into bile. It is not clear whether the primary step in this process is flopping of cholesterol from the inner to the outer leaflet of the canalicular membrane, with desorption by mixed micelles, or decreasing of the activ...

Journal: :Molecular medicine reports 2014
Ge Wu Gui-Bin Li Ming Yao Dong-Qing Zhang Bin Dai Chuan-Jing Ju Ming Han

ATP-binding cassette sub-family G member 5 (ABCG5) and ABCG8 are members of an ATP-binding cassette transporter superfamily. ABCG5 and ABCG8 variants affected serum levels of cholesterol and were considered as risk factors for coronary heart disease (CHD). The present control study analyzed ABCG5 and ABCG8 variants in a population for association with the risk of CHD. A total of 417 CHD patient...

2010
Anshika Srivastava Naveen Garg Anvesha Srivastava Kshitij Srivastava Balraj Mittal

BACKGROUND ATP-binding cassette transporter ABCG8 plays an important role in excretion of cholesterol from liver. Common genetic polymorphisms in ABCG8 gene may genetically predispose an individual to coronary artery disease (CAD) along with response to atorvastatin therapy. Thus, we aimed to examine the role of ABCG8 D19H polymorphism (rs11887534) in susceptibility to CAD and its influence on ...

Journal: :IUPHAR/BPS guide to pharmacology CITE 2023

This family of 'half-transporters' act as homo- or heterodimers; particularly ABCG5 and ABCG8 are thought to be obligate heterodimers. The ABCG5/ABCG heterodimer sterol transporter structure has been determined [6], suggesting an extensive intracellular nucleotide binding domain linked the transmembrane domains by a fold in primary sequence. functional ABCG2 appears homodimer with structural si...

Journal: :Journal of lipid research 2004
F Jeffrey Field Ella Born Satya N Mathur

Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin. ABCA1, ATP binding cassette G1 (ABCG1), ABCG5, ABCG8, and Niemann-Pick C1-like 1 (NPC1L1) mRNA levels were then estimated in duodenum, jejunum, and ileum. Plasma cholesterol was decreased by 36% and 94% in a...

Journal: :Journal of lipid research 2004
Li-Ping Duan Helen H Wang David Q-H Wang

In the present study, we investigated whether intestinal sterol efflux transporters Abcg5 and Abcg8 play a major role in determining variations in cholesterol (Ch) absorption efficiency, and we compared the physiological functions of the duodenal, jejunal, and ileal Abcg5 and Abcg8 on the absorption of Ch and sitostanol in inbred mice challenged with various amounts of Ch, sitostanol, hydrophil...

2014
Shingo Suzuki Tsuyoshi Shuto Takashi Sato Masayuki Kaneko Tappei Takada Mary Ann Suico Douglas M. Cyr Hiroshi Suzuki Hirofumi Kai

N-glycosylation of proteins in endoplasmic reticulum is critical for protein quality control. We showed here a post-translational N-glycosylation affected by the HRD1 E3 ubiquitin ligase. Both WT- and E3-defective C329S-HRD1 decreased the level of high mannose form of ABCG8, a protein that heterodimerizes with ABCG5 to control sterol balance. Meanwhile, HRD1 increased the non-glycosylated ABCG8...

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