نتایج جستجو برای: abca1

تعداد نتایج: 1947  

Coronary artery disease (CAD) is a common health problem in Iranian population. ATP binding cassette transporter A1 (ABCA1) plays central role in the efflux of the cholesterol from peripheral tissues back to liver. Inactivation of ABCA1 by epigenetic change such as DNA methylation may contribute to the development of CAD. The present study investigated the association between promoter DNA methy...

Journal: :Frontiers in Physiology 2023

ATP binding cassette transporter A1 (ABCA1) limits the formation of high density lipoproteins (HDL) as genetic loss ABCA1 function causes virtual HDL deficiency in patients with Tangier disease. Mice a hepatocyte-specific knockout (Abca1 HSKO) have 20% wild type (WT) plasma HDL-cholesterol levels, suggesting major contribution hepatic to phenotype. Whether sphingolipids are reduced disease and ...

جوادی, ابراهیم, حشمت, رامین, دوستی, محمود, ملک‌پور ‌دهکردی, زهرا, نوربخش, میترا, پاک‌نژاد, ملیحه, گرایش نژاد, سیاوش, یاسا, نرگس,

Background: ATP-binding cassette transporter A1 (ABCA1) is a key mediator of cholesterol efflux to apoA-I in lipid-laden macrophages, the first step of reverse cholesterol transport (RCT) in vivo and a critical step in preventing atherosclerosis. Enhanced ABCA1 expression may inhibit foam cell formation and consequently reduce atherogenic risk. On the other hand, garlic, Allium sati...

Journal: :Journal of lipid research 2007
Veronica Hirsch-Reinshagen Jennifer Y Chan Anna Wilkinson Tracie Tanaka Jianjia Fan George Ou Luis F Maia Roshni R Singaraja Michael R Hayden Cheryl L Wellington

ABCA1-deficient mice have low levels of poorly lipidated apolipoprotein E (apoE) and exhibit increased amyloid load. To test whether excess ABCA1 protects from amyloid deposition, we crossed APP/PS1 mice to ABCA1 bacterial artificial chromosome (BAC) transgenic mice. Compared with wild-type animals, the ABCA1 BAC led to a 50% increase in cortical ABCA1 protein and a 15% increase in apoE abundan...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2003
Nan Wang Alan R Tall

ATP-binding cassette transporter A1 (ABCA1) plays a major role in cholesterol homeostasis and HDL metabolism. ABCA1 mediates cellular cholesterol and phospholipid efflux to lipid-poor apolipoproteins, and upregulation of ABCA1 activity is antiatherogenic. ApoA-I, the major apolipoprotein component of HDL, promotes ABCA1-mediated cholesterol and phospholipid efflux, probably by directly binding ...

2014
Willeke de Haan Joanna M. Karasinska Piers Ruddle Michael R. Hayden

Low HDL is a risk factor for the development of type 2 diabetes. Hepatic ABCA1 is the rate-limiting protein in HDL biogenesis, and mice lacking hepatic ABCA1 (ABCA1) have very low plasma HDL concentrations. To investigate the role of hepatic ABCA1 in glucose tolerance and b-cell function, we used ABCA1 mice, which showed impaired glucose tolerance without changes in insulin sensitivity. Insulin...

Journal: :Atherosclerosis 2009
Yan-Wei Hu Xin Ma Xiao-Xu Li Xie-Hong Liu Ji Xiao Zhong-Cheng Mo Jim Xiang Duan-Fang Liao Chao-Ke Tang

ABCA1 is a key mediator of cholesterol efflux to apoA-I in cholesterol loaded macrophages, a first step of RCT in vivo. Unsaturated fatty acids can inhibit cholesterol efflux from macrophages by increasing degradation of ABCA1. However, the detailed mechanisms of ABCA1 regulation by unsaturated fatty acids are not fully understood. In the present study, we investigated the effects of EPA on ABC...

Journal: :Food Science and Technology 2023

In order to reveal the inhibitory effect of pomegranate punicalagin on macrophage foam cell formation and its possible mechanism, Raw264.7 macrophages were as experimental carrier detect cholesterol accumulation outflow, evaluate regulation related genes CD36, PPARγ outflow ABCA1/G1, LXRα by Western-Blot method. The results showed that can inhibit in raw264.7 due restraining PPARγ-CD36 expressi...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2007
Ming-Dong Wang Vivian Franklin Yves L Marcel

BACKGROUND ATP-binding cassette transporter A1 (ABCA1) is a key mediator of cholesterol efflux to apoA-I in cholesterol loaded macrophages, a first step of reverse cholesterol transport (RCT) in vivo. Macrophage specific abca1 inactivation or overexpression, respectively, accelerated or suppressed the development of atherosclerosis in mouse models. However, it is yet to be established that the ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2008
Rui Lu Reijiro Arakawa Chisato Ito-Osumi Noriyuki Iwamoto Shinji Yokoyama

OBJECTIVE Calpain-mediated proteolysis is one of the major regulatory factors for activity of ATP-binding cassette transporter (ABC) A1. Helical apolipoproteins protect ABCA1 against this degradation and increase generation of HDL. We investigated the mechanism for this reaction focusing on roles of endocytotic internalization of ABCA1. METHODS AND RESULTS Surface ABCA1 was labeled with bioti...

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