نتایج جستجو برای: a0201

تعداد نتایج: 43  

Journal: :International immunology 2007
W Yang E L Beaudoin L Lu R A Du Pasquier M J Kuroda R A Willemsen I J Koralnik R P Junghans

Progressive multifocal leukoencephalopathy (PML) is a deadly brain disease caused by the polyomavirus JC (JCV). The aim of this study is to develop 'designer T cells' armed with anti-JCV TCR-based chimeric immune receptors (CIRs) by gene modification for PML immunotherapy. Two T cell lines specific to two dominant CTL epitopes derived from JCV VP1 protein (termed p36 and p100) from an HLA-A0201...

Journal: :Acta virologica 2011
Y J Guo Y Zhu S H Sun

Cytotoxic T lymphocyte (CTL) epitopes in the X protein (HBx) of hepatitis B virus (HBV) may play a key role in the viral control and liver damage. The aim of this study was to identify and study the function of HLA-A0201 restricted CTL epitopes in HBx of HBV genotypes B and C that are epidemic in China. Four nonapeptides signed HBx1: VLCLRPVGA, HBx2: CLFKDWEEL, HBx3: VLHKRTLGL, and HBx4: HLSLRG...

Journal: :Cancer research 2000
J Dannull P A Diener L Prikler G Fürstenberger T Cerny U Schmid D K Ackermann M Groettrup

Immunotherapy of prostate cancer (CaP) may be a promising novel treatment option for the management of advanced CaP. However, the lack of suitable tumor antigens remains a major obstacle for the rational design of vaccines. To characterize potential CaP antigens, we determined the mRNA expression of the prostate-specific genes C1, C2, C5, PAGE-1, and prostate stem cell antigen (PSCA) in hormone...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2000
A Chersi F di Modugno L Rosano

The binding affinity of synthetic nonapeptides to human leucocyte antigens (HLA) molecules of the A0201 allotype, the most common in Caucasian, is enhanced or reduced by suitable amino acid substitutions at position 4, as a result of increased or decreased chain flexibility. A higher flexibility of the bond at this position correlates with an easier accommodation of the fragment into the HLA gr...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Ekaterina S Doubrovina Mikhail M Doubrovin Sangyull Lee Jae-Hung Shieh Glen Heller Eric Pamer Richard J O'Reilly

The Wilms tumor protein (WT1) is overexpressed in most acute and chronic leukemias. To develop a practicable, clinically applicable approach for generation of WT1-specific T cells and to comparatively evaluate the immunogenicity of WT1 in normal individuals, we sensitized T cells from 13 HLA-A0201+ and 5 HLA-A2402+ donors with autologous EBV-transformed B cells or cytokine-activated monocytes, ...

2010
Michael Linnebacher Anne Wienck Inga Boeck Ernst Klar

Microsatellite instability (MSI-H) induced by defects of the DNA mismatch repair system results in insertion or deletion of single nucleotides at short repetitive DNA sequences. About 15% of sporadic and approximately 90% of hereditary nonpolyposis colorectal cancers display MSI-H. When affecting coding regions, MSI-H results in frameshift mutations and expression of corresponding frameshift pe...

Journal: :Journal of medicinal chemistry 2005
Pingping Guan Irini A Doytchinova Valerie A Walshe Persephone Borrow Darren R Flower

Amino acid descriptors are often used in quantitative structure-activity relationship (QSAR) analysis of proteins and peptides. In the present study, descriptors were used to characterize peptides binding to the human MHC allele HLA-A0201. Two sets of amino acid descriptors were chosen: 93 descriptors taken from the amino acid descriptor database AAindex and the z descriptors defined by Wold an...

2003
Paul J. Lehner Eddie C. Y. Wang Paul A. H. Moss Sheila Williams Kaye Platt Steven M. Friedman John I. Bell Leszek K. Borysiewicz

The major histocompatibility complex class I-restricted cytotoxic T lymphocyte (CTL) response is important in the clearance of viral infections in humans. After influenza A infection, a peptide from the matrix protein, M58-66, is presented in the context of the MHC allele HLA-A0201 and the resulting CTL response is detectable in most HLA-A0201 subjects. An initial study suggested that M58-66-sp...

Journal: :The Journal of Experimental Medicine 1995
P J Lehner E C Wang P A Moss S Williams K Platt S M Friedman J I Bell L K Borysiewicz

The major histocompatibility complex class I-restricted cytotoxic T lymphocyte (CTL) response is important in the clearance of viral infections in humans. After influenza A infection, a peptide from the matrix protein, M58-66, is presented in the context of the MHC allele HLA-A0201 and the resulting CTL response is detectable in most HLA-A0201 subjects. An initial study suggested that M58-66-sp...

Journal: :Journal of medicinal chemistry 1999
D Rognan S L Lauemoller A Holm S Buus V Tschinke

A simple and fast free energy scoring function (Fresno) has been developed to predict the binding free energy of peptides to class I major histocompatibility (MHC) proteins. It differs from existing scoring functions mainly by the explicit treatment of ligand desolvation and of unfavorable protein-ligand contacts. Thus, it may be particularly useful in predicting binding affinities from three-d...

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