background: factor xiii (fxiii) is a heterotetramer composing two subunits including fxiii-a and fxiii-b. several common gene variations were observed in fxiii-a gene with obvious ethnic difference. this study assessed pattern of tyr204phe as a common fxiii-a gene variation among iranian population. materials and methods: this study was conducted on eighty iranian unrelated individuals. genotyp...

background: a. bovis and a. phagocytophilium are leukocytotropic agents of bovine anaplasmosis. they are obligate intracellular bacteria that can infect and cause anaplasmosis in human and animals. therefore, this study was carried out to detect a. bovis and a. phagocytophilum in naturally infected dairy cattle in isfahan using molecular techniques. materials and methods: in this study a total ...

background: haemophilia a (ha) is an x-linked bleeding disorder caused by the absence or reduced activity of coagulation factor viii (fviii). coagulation factors are a group of related proteins that are essential for the formation of blood clots. the aim of this study was to genotype the coagulation factor viii gene mutations using inverse shifting pcr (is-pcr) in an iranian family with severe ...

background and objectives: rapid clinical manifestation/progression of the meningococcal meningitis and lacunae in conventional bacteriological test often encourages indiscriminate use of antibiotics much before the etiology is established. this study was planned to evaluate ctra pcr for rapid molecular detection. in addition, multiplex pcr and sequencing was done for serogroup prediction to pr...

objective(s):helicobacter pylori infection occurs worldwide, but the prevalence of this infection varies greatly among different countries and population groups. the aim of this study was to determine the seroprevalence of anti-helicobacter pylori and anti-cytotoxin-associated gene a (caga) antibodies in asymptomatic healthy population in the center of iran and to investigate the relation with ...

b a ckground: the objective was to investigate the relationship between serum interleukin-18 (il-18), pentraxin 3 (ptx3), and high-sensitivity c-reactive protein (hs-crp) levels with body mass index (bmi) and abdominal obesity and also the interaction between genetic variants of apolipoprotein a-ii (apo a-ii) and obesity on the levels of these factors in type 2 diabetes patients (t2d). m ethods...

multiple sclerosis (ms) is a chronic inflammatory disease that leads to degeneration of the brain and spinal tissue. imbalances of cd4+ t cells including thelper1 (th1)/thelper2 (th2) and thelper17 (th17)/tregulatory (treg), their secreted cytokines and gene expressions, are important aspects of in immunopathogenesis of ms. vitamin a and its metabolites can regulate the immune system and appear...

conclusions the results indicated that there was a positive association between susceptibility to chronic hbv infection and tnf-α polymorphism. in addition, hbv patients carrying -308 gg, -857 cc, and -863 aa genotypes with lower serum levels of tnf-α had an increased risk of infection. background the host genetic background regulates the natural history of chronic hepatitis b virus (hbv) infec...