Pederine, a drug extracted from the coleopter Paederus fuscipes, inhibits the growth of in vitro cultured cell lines at concentrations of the order of 1.5 nanogram/ml. Cytological examination shows a generalized cytotoxic effect. Analysis of macromolecular syntheses by the use of radioactive precursors shows that pederine causes an almost immediate block of protein and DNA synthesis, without af...

Paederus dermatitis is a peculiar contact dermatitis caused by pederine contained in the hemolimph of a small insect of the genus Paederus. It is characterized by vesico-pustulous eruption arising over an erythematous background, of sudden onset, over exposed areas of the body, and the history of outdoor activities. Diagnosis is based on the typical clinical features and the epidemiological con...

objective(s):cervical cancer is a malignancy that is the second most common cause of death from cancer in women throughout the world. paederus beetle (paederus fuscipes) extract (pbe), contains bioactive compounds such as pederine which has cytotoxic properties and blocks dna and protein synthesis at very low concentrations. in this investigation we tried to determine the effects co-treatment w...

OBJECTIVES Cervical cancer is a malignancy that is the second most common cause of death from cancer in women throughout the world. Paederus beetle (Paederus fuscipes) extract (PBE), contains bioactive compounds such as pederine which has cytotoxic properties and blocks DNA and protein synthesis at very low concentrations. In this investigation we tried to determine the effects co-treatment wit...

A number of cytotoxic drugs (mitotic poisons, chemical mutagens, bifunctional alkylating agents, inhibitors of DNA, RNA, or protein synthesis, for a total of 18 agents) have been tested for differences in their lethal effects through the generation cycle of HeLa and Chinese ham ster cells in culture. The patterns of age response of cells to each group of agents show some features in common: mit...

Objective(s):Cervical cancer is a malignancy that is the second most common cause of death from cancer in women throughout the world. Paederus beetle (Paederus fuscipes) extract (PBE), contains bioactive compounds such as pederine which has cytotoxic properties and blocks DNA and protein synthesis at very low concentrations. In this investigation we tried to determine the effects co-treatment w...