نتایج جستجو برای: Null Genotype
تعداد نتایج: 136240 فیلتر نتایج به سال:
Introduction: GSTM and GSTT are subclasses of glutathione s-transferase that is present on human sperm surface and plays an important role against oxidative stress. This study aimed to investigate the polymorphisms of GSTT1 and GSTM1 in regard to sperm parameters. Methods: This case-control study involved 46 men with varicocele and 48 men without varicocele. Semen analyses were carried out ac...
background: the glutathione s-transferase (gst) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. the expression of many of these cancer susceptibility enzymes is genetically polymorphic. an increased frequency of gst-null genotypes has been associated with several malignancies. objective: to investigate the rate of gstt1 and gstm1 null ge...
no association of gstm1 null polymorphism with endometriosis in women from central and southern iran
background: endometriosis is one of the most common gynecologic disorders. it is a complex trait and both genetic and environmental factors have been implicated in its pathogenesis. there is growing evidence indicating that exposure to environmental contaminants is a risk factor for endometriosis. glutathione-s-transferase m1 (gstm1) is one of the genes involved in detoxification of endogenous ...
Background and purpose: Glutathion S-transferase (GSTs) are a family of detoxification phase II enzymes that catalyze the conjugation of carcinogenic and cytotoxic componds with glutathion. GSTs are polymorphic and deletion of GSTM1 and GSTT1 polymorphism is caused by lack of enzyme production that lead to loss of antioxidant activity. In this study, we examined the frequency of GSTM1 and G...
Background & Aims: Recurrent Pregnancy Loss (RPL) is defined as two or more consecutive spontaneous abortions. Glutathione S-transferase genes produce isoenzymes that protect embryo against oxidative stress. The aim of this study was to determine the removal of the two genes, GSTT1 and GSTM1 in male partners of couples having RPL. Materials & Methods: A case-control study of 102 cases w...
background : progression of systemic lupus erythematosus (sle) could be due to oxidative stress especially through reactive oxygen species (ros). detoxification of ros is largely performed by glutathione s-transferases (gsts), therefore polymorphisms of gstm1, gstt1 and gstp1 genes which decrease enzymes activity could affect sle susceptibility. the aim of this study was to determine the effect...
background: acute myeloid leukemia, as most cancers, results from exposure to carcinogens and an impaired inherited individual capacity to eliminate xenobiotics. the present case-control study measures the relationship between glutathione s-transferase (gst) t1 and m1 null genotypes and the risk of acute myeloid leukemia. methods: we identified the gstt1 andgstm1 genotypes by multiplex polymera...
Glutathione S-transferases (GSTs) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. The human GSTs are divided into four classes: alpha, mu, pi and theta. Previous studies indicated that the absence of the Glutathione S-Transferase M1 (GSTM1) protein correlated with an increased risk of developing some types of cancers. Association between spe...
the aim of this study was to assess the possible association between genetic polymorphisms of the glutathione s-transferase (gst) gene family and the risk of the development of metabolic syndrome (ms) in zoroastrian females in yazd, iran.in this case-control study, gstm1, t1, and p1 polymorphisms were genotyped in 51 randomly selected ms patients and 50 randomly selected healthy controls on feb...
Background: Pi-GST and Mu-GST are subclasses of glutathione S-transferase that present on human sperm surface and play an important role against oxidative stress. Therefore, any defects in the enzyme activity may be associated with male infertility.In this study the polymorphisms of GSTM1 and GSTP1 in association with enzyme activity and sperm parameters were studied. Methods: This case-contro...
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