background and objectives:the plants of genus artemisia (asteraceae) have been conventionally used for prevention and medication of a number of ailments. in the present research, ten extracts with different polarities from aerial parts of two artemisia species, a. kopetdaghensis and a. turcomanica were evaluated for their potential anti-malarial properties. methods: the plant materials were ext...

  Background :Wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. Recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. We investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (HSV-1) in cell culture.   Methods : In-vitro...

background :wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. we investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (hsv-1) in cell culture.   methods : in-vitro c...

members of the genus bacillus are among the most promising candidates for biological control of plant pathogenic bacteria. in this study, cell free supernatants of three strains b. subtilis utb96, b. subtilis utb1 and b. subtilis utb70 against aspergillus flavus r5 were investigated using dual culture assay. strain b. subtilis utb96 showed the highest inhibition effect. thin lyer chromatography...

introduction: cell culture is a process in which the cells ware isolated from original tissue, dispersed in liquid media and then placed in culture plate where the cells adhere together and propagate. today, this method is used for assessment of cell toxicity, its mechanisms and effect of different compounds on intracellular components. methods: clonogenic assay was used for assessment of cell ...

improving the solubility of non-soluble herbal materials is an issue of interest in cell culture based experiments. evaluating the biological activity of these materials could become possible with the aid of cosolvents/surfactants which obviously should have little or no cytotoxic activity. in the present study, the cytotoxic activity of six cosolvents/surfactants: ethanol, methanol, tween 20 a...

background: lactoferrin is a glycoprotein with a molecular weight of 80 kda, as a member of the transferring family. in recent investigations the important biological properties such as anti microbial, antiviral and anticancer activity of lactoferrin were studied. in the present study, the effect of antitumor induced by lactoferin was evaluated on stomach cancer cell ags. materials and methods:...

the cytotoxicity of the biomaterials is a key issue that should be addressed prior to pre-clinical applications. this study was designed to evaluate and compare the cytotoxixity of two forms of bioactive glasses:nanopowder:andmicropowder. human hgf1-pi53 gingival fibroblast cells were used to evaluate the cytotoxicity of 0.5, 1, 1.5, 2, 5, 10, 15 and 20 mg/ml concentrations of the two bioactive...

objective: irinotecan is a botanical derivative and an anti-cancer drug with cytotoxic and genotoxic effects. the present study evaluated the effect of lactobacillus plantarum a7 on the genotoxic activity of irinotecan in a hepatocellular carcinoma cell line (hepg2) by comet assay. materials and methods: hepg2 were incubated with irinotecan (100 µm), heat-killed cells (0.025 µg/ml) + irinotecan...