نتایج جستجو برای: Anticonvulsant, antitubercular
تعداد نتایج: 6799 فیلتر نتایج به سال:
methyl indole derivative of some 6-aryl-4,5-dihydropyridazin-3(2h)-ones (3a-e) were synthesized by mannich reaction and evaluated as anticonvulsant against mes (50ma, for 2sec), inh (250mg/kg), scptz (80mg/kg) and str (3mg/kg) induced convulsion methods at 50 mg/kg dose level. all compounds 3a-e were also evaluated as antitubercular agent against m. tuberculosis h37rv by maba method. all compou...
Methyl indole derivative of some 6-aryl-4,5-dihydropyridazin-3(2H)-ones (3a-e) were synthesized by Mannich reaction and evaluated as anticonvulsant against MES (50mA, for 2sec), INH (250mg/kg), scPTZ (80mg/kg) and STR (3mg/kg) induced convulsion methods at 50 mg/kg dose level. All compounds 3a-e were also evaluated as antitubercular agent against M. tuberculosis H37Rv by MABA method. All compou...
Biologically active heterocyclic compounds comprise of largest & manifold family organic compounds. These include Quinolines, Quinazolines, Aminoquinolines, etc and their derivatives. They exhibit multi-faceted biological properties like analgesic, anti-inflammatory, anticonvulsant, antibacterial, antifungal, antidepressant, anticancer, antitubercular &antihistaminic. are considered to ...
Triazole is a five member heterocyclic nucleus has attracted a wide consideration in exploration for the new remedial agents. This nucleus acts very important role in biological fields for various biologically active molecules. The chemistry of triazole compounds has expected considerable interest due to their synthetic and effective biological properties likes analgesic, antinflammatory, antio...
Some 6-aryl-4,5-dihydropyridazin-3(2H)-one compounds (2a-f) were synthesized and evaluated for their in-vivo anticonvulsant activities against maximal electro shock (MES) and isoniazid (INH) induced seizure methods at 50mg/kg dose level. Neurotoxicity of all compounds (2a-f) was also tested at 50, 100 and 200mg/kg dose level. The in-vitro antitubercular activity was evaluated against Mycobacter...
Thiazolidinediones are sulfur containing pentacyclic compounds that are widely found throughout nature in various forms. Thiazolidinedione nucleus is present in numerous biological compounds, e.g., anti-malarial, antimicrobial, anti-mycobacterium, anticonvulsant, antiviral, anticancer, anti-inflammatory, antioxidant, anti-HIV (human immunodeficiency virus) and antitubercular agent. However, owi...
Pyridazine and thiazole derivatives have various biological activities such as antimicrobial, analgesic, anticancer, anticonvulsant, antitubercular other anticipated properties. Chitosan can be used heterogeneous phase transfer basic biocatalyst in heterocyclic syntheses. Novel 1-thiazolyl-pyridazinedione were prepared via multicomponent synthesis under microwave irradiation ecofriendly energy ...
Isatin is an endogenous compound identified in humans that possesses a wide range of biological activities. Isatin has anxiogenic, sedative, anticonvulsant activities and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro. A series of p-substituted isatin semicarbazones have shown anticonvulsant activity in MES, scPTZ and scSTY tests. Various isatin-N-Mannich bases of ...
Due to its beneficial natural and pharmacological properties, heterocyclic element analogues derivatives have recently received a lot of attention. One the frequently occurring nuclei in both marine grow solutions is benzothiazole. A favoured bicyclist band method with numerous utilizations It well known for exhibiting broad variety activities, including those that are anticancer, antiviral, an...
Mannich bases are beta-amino ketone-carrying compounds that the end products of reaction. The reaction is essential in synthesis nitrogen-containing compounds. reaction, a nucleophilic addition forms carbon-carbon bonds, employed numerous natural products, drugs and other There several aminoalkyl chain bearing with high curative value, such as fluoxetine, atropine, ethacrynic acid, trihexypheni...
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