introduction: this study was launched to evaluate the sensitivity and specificity of 99mtc-ciprofloxacin to distinguish infection foci induced by staphylococcus aureus and inflammation lesions induced by carrageenan in the rat foot in comparison with 67ga-citrate scintigraphy. methods: the labeling and quality control of 99mtc-ciprofloxacin kits have been performed according to the manufacture...

introduction: radiolabeled antibiotics are being used for the specific diagnosis of infection by exploiting their specific binding properties to the bacterial components, thereby making it possible to differentiate infection from sterile lesions. the aim of this work was to prepare and evaluate a freeze-dried kit of ciprofloxacin designed for the labeling with 99mtc. methods: factors like amou...

The use of radiolabelled antibiotics is fast emerging as a promising diagnostic test for the detection of infective lesions, because of their specific binding to the bacterial component. Ciprofloxacin is a broad-spectrum antibiotic that has been used as a radiolabelled antibiotic in both the diagnosis of infections in rabbits and in clinical trials on humans. The diagnosis of skeletal microbial...

BACKGROUND/AIM 99mTc-ciprofloxacin is a radiopharmaceutical preparation sintetized to improve diagnostic accuracy of bacterial infections in human tissues. It is mostly applied in diagnosis of bone and joint infections. Many papers have confirmed its sensitivity to infection, but newer papers argued its specificity. The aim of this study was to compare the results of visual analysis of scintigr...

Background/Aim. There is a constant and dramatic in-crease in hip knee prosthetic implantations worldwide. However, decrease the percentage of failed (infected) not significant (0.5% up to 2%). The real challenge whether joint loosening was caused by aseptic inflammation or infection. aim present study attempt distinguish sterile from infection patients with painful joint. Another objective det...

The use of radiopharmaceuticals for the diagnosis of infection is increasing due to their ability to distinguish between septic and aseptic inflammation. The aim of this study was to analyze the intracellular accumulation of technetium-99m-ciprofloxacin in strains of Staphylococcus aureus and Pseudomonas aeruginosa harboring an overexpression of NorA and MexAB-OprM, respectively.