نتایج جستجو برای: 907
تعداد نتایج: 1349 فیلتر نتایج به سال:
Many monoclonal antibodies (mAbs) and other protein drugs have targets usually residing within tissues, making tissue concentrations of mAbs relevant to their pharmacologic effects. Therefore, knowledge of tissue distribution kinetics is important to better understand their pharmacokinetics and pharmacodynamics. The tissue distribution of mAbs is affected by many physiologic factors that may be...
نظام اداری و سیاسی حکومت صفویه به ویژه قبل از اصلاحات شاه عباس اول بسیار پیچیده و مبهم بوده است. از مهمترین مناصب موجود در آن حکومت منصب وکالت و وزارت است. نقش و اهمیت وکالت به عنوان نائب و قائم مقام شاه ، و وزیر به عنوان رئیس دیوانسالاری اداری در دوره صفویه ، متاثر بود. به منظور ایجاد هماهنگی در عناصر نامتجانس حکومت کارکرد تازه ای یافت و در کنار منصب وزارت که در حکومت صفوی تداوم یافته بود منشا...
Nicholas T Janssen and Rorik A Peterson, Ph.D. Dr. Richard W Wies, Ph.D., P.E. Department of Mechanical Engineering Department of Computer and Electrical Engineering University of Alaska, Fairbanks University of Alaska, Fairbanks 306 Tanana Dr, Fairbanks, Alaska 99775 306 Tanana Dr, Fairbanks, Alaska 99775 United States United States [email protected] (907) 474-5887 [email protected] (907)...
OBJECTIVE To compare readings obtained using two automated blood pressure (BP) recording devices, BpTRU and Omron 907, in a clinical setting. METHODS Two series of 50 patients attending a hypertension unit for 24-h ambulatory BP monitoring had BP recorded either every 1 or every 2 min using BpTRU and Omron 907 devices with the order of the measurements being randomized. RESULTS No significa...
Phosphoinositide 3-kinase (PI3K) and Myc are known to cooperate in promoting the survival and growth of a variety of B-cell lymphomas. While currently there are no small molecule inhibitors of Myc protein, histone deacetylase (HDAC) inhibitors have been shown to reduce levels of Myc protein by suppressing its transcription. We assessed the efficacy of CUDC-907, a new rationally designed dual in...
PURPOSE Given that histone deacetylase (HDAC) inhibitors are known to induce multiple epigenetic modifications affecting signaling networks and act synergistically with phosphatidylinositol 3-kinase (PI3K) inhibitors, we developed a strategy to simultaneously inhibit HDACs and PI3K in cancer cells. EXPERIMENTAL DESIGN We constructed dual-acting inhibitors by incorporating HDAC inhibitory func...
Inflammation in adipose tissue is a characteristic of obesity and the metabolic syndrome. It is suggested that the endocannabinoid system is involved in the regulation of inflammatory and angiogenic processes within the tissue. Human subcutaneous preadipocytes (Zen Bio) were used as the source of human preadipocytes or adipocytes. Gene expression was examined by RT-PCR and real-time PCR. The se...
JTE-907 [N-(benzo[1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxamide] was evaluated in vitro and in vivo as a novel selective ligand for cannabinoid receptor of peripheral type (CB2). The compound binds with high affinity to human CB2 or mouse CB2 expressed on CHO cell membrane and to rat CB2 on splenocytes. The K(i) affinities for human, mouse, and rat CB2 we...
The general and galvanic corrosion of high strength steel (980), high strength steel (907) and high strength steel (921A) in seawater at elevated temperatures has been analyzed using electrochemical measurements and a zero-resistance ammeter (ZRA). After the tests, the surface morphologies of the samples have been detected by SEM. Results show galvanic corrosion behavior of 980/907/921A fulfill...
CUDC-907 is a first-in-class, oral small molecule inhibitor of both HDAC (class I and II) and PI3K (class Iα, β, and δ) enzymes, with demonstrated anti-tumor activity in multiple pre-clinical models, including MYC-driven ones. In this report, we present the safety and preliminary activity results of CUDC-907, with and without rituximab, in patients with relapsed/refractory diffuse large B-cell ...
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