objective(s): multiple sclerosis (ms) is an autoimmune demyelinating disease of the central nervous system (cns) with unknown etiology. various genetics and environmental factors contribute to the pathogenesis of the disease. the interleukin-7 receptor alpha chain (il-7ra) was identified as the first non-major histocompatibility complex (non-mhc) ms susceptibility locus. in this study we are tr...

background:  multiple  sclerosis  (ms) is a  chronic inflammatory  demyelinating  and  neurodegenerative disease  of central  nervous  system  with unknown  causes. etiology of ms involves  both  genetic  and  environment factors.  the  interleukin  7   receptor   (il7r)   gene   is  a promising candidate  for ms, because its involvement in the autoimmunity, regulation of the t-cell homeostasis...

conclusions the current study adds evidence to the association of tnf-α gene polymorphism and ms in this southern south iranian population which is consistent with the genetic analysis of ms in europeans (games) project reports and these two alleles reported in this study may be one of the genetic risk factor for ms. furthermore, this data can be used to build the iranian gene bank for future s...

Objective(s): Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) with unknown etiology. Various genetics and environmental factors contribute to the pathogenesis of the disease. The interleukin-7 receptor alpha chain (IL-7Ra) was identified as the first non-major histocompatibility complex (non-MHC) MS susceptibility locus. In this study we are tr...

multiple sclerosis (ms) is a multifactorial disease (caused by both environmental and genetic features) that could results from a demyelination of the myelin sheath. subsequently, it leads to many scars or lesions in different places within the central nervous system. the symptoms that occur depend on the site and rigorousness of the lesions and this is why people with ms experience different s...

TNFα is an inflammatory cytokine and the caspase and apoptotic processes can be activated by TNFα There are two classes of TNFα (solTNF and tmTNFα) which are important from the receptor aspect, so that solTNFα and tmTNFα can attach to the TNFR1, but tmTNFα just attaches to the TNFR2. Microglia cells are resident immune cells of the central nervous ...

multiple sclerosis (ms) is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. the main pathogenesis of ms has long been thought to be an immune mediated disorder of the central nervous system. the function of the immune system is under the influence of vitamin d which as a modulator of immune response could play a...

Multiple sclerosis is a chronic, often disabling, disease of the central nervous system affecting more than 1 in 1,000 people in most western countries. The inflammatory lesions typical of multiple sclerosis show autoimmune features and depend partly on genetic factors. Of these genetic factors, only the HLA gene complex has been repeatedly confirmed to be associated with multiple sclerosis, de...

BACKGROUND Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune demyelinating diseases of the central nerve system. Interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Rα) were proved to be important in the pathogenesis of both diseases because of the roles they played in the differentiations of autoimmune lymphocytes. The variants of both genes had been identified to be...

previous studies have demonstrated that vascular endothelial growth factor (vegf) can trigger angiogenesis as well as inflammation through binding to its membranous receptor-1 on endothelial and inflammatory cells. we aimed to correlate the circulatory number of cells expressing such receptor as well as the serum level of vegf and the soluble form of its receptor-1 (svegfr1) to the severity of ...